Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Glioblastoma (GBM) is the most common and aggressive central nervous system tumor,
requiring multimodal management. Due to its malignant behavior and infiltrative growth …

Down-regulation of miR-146b-5p contributes to tumorigenesis in several human cancers.
However, the relevance of miR-146b-5p to prognosis, proliferation and apoptosis in gliomas …

Question Should patients with previously diagnosed malignant glioma who are suspected of
experiencing progression of the neoplasm process undergo repeat open surgical resection …

The mostly aggressive and extremely malignant type of central nervous system is
Glioblastoma (GBM), which is characterized by an extremely short average survival time of …

A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate
axial embryonic patterning. Here we identify the tumor suppressor Protein tyrosine …

The vast majority of malignant gliomas relapse after surgery and standard radio-
chemotherapy. Novel molecular and cellular therapies are thus being developed, targeting …

Gliomas are the most common primary brain tumors with high mortality. The treatment for
gliomas is largely limited due to its uncomprehending pathological mechanism. Here we …

Glioblastoma is a deadly disease that has not shown improvement despite the development
of new diagnostic tools and innovative targeted therapies. This grim outcome is mainly …

Glioblastoma multiforme (GBM) is the high-grade primary glioma in adults. Temozolomide
(TMZ), an alkylating agent of the imidazotetrazine series, is a first-line chemotherapeutic …