Intake of salt is a biological imperative, inextricably woven into physiological systems,
human societies and global culture. However, excessive salt intake is associated with high …

Five canonical tastes, bitter, sweet, umami (amino acid), salty, and sour (acid), are detected
by animals as diverse as fruit flies and humans, consistent with a near-universal drive to …

Taste receptors function as one of the interfaces between internal and external milieus.
Taste receptors for sweet and umami (T1R [taste receptor, type 1]), bitter (T2R [taste …

TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory
neurons involved in pain sensation and also at a number of other neuronal and non …

Responses in the amiloride-insensitive (AI) pathway, one of the two pathways mediating
salty taste in mammals, are modulated by the size of the anion of a salt. This “anion effect” …

How taste buds detect NaCl remains poorly understood. Among other problems, applying
taste-relevant concentrations of NaCl (50–500 mm) onto isolated taste buds or cells exposes …

The gustatory system plays a critical role in determining food preferences and food intake, in
addition to nutritive, energy and electrolyte balance. Fine tuning of the gustatory system is …

Sodium (Na+) is crucial for numerous homeostatic processes in the body and,
consequentially, its levels are tightly regulated by multiple organ systems. Sodium is …

The gustatory system detects and informs us about the nature of various chemicals we put in
our mouth. Some of these have nutritive value (sugars, amino acids, salts, and fats) and are …

Mammalian taste buds are comprised of specialized neuroepithelial cells that act as sensors
for molecules that provide nutrition (eg, carbohydrates, amino acids, and salts) and those …