Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Altered glycosylation in cancer: A promising target for biomarkers and therapeutics

D Thomas, AK Rathinavel, P Radhakrishnan - Biochimica et Biophysica …, 2021 - Elsevier
Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …

Mass spectrometry-based protein footprinting for higher-order structure analysis: fundamentals and applications

XR Liu, MM Zhang, ML Gross - Chemical reviews, 2020 - ACS Publications
Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Comprehensive characterization of N-and O-glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2

A Shajahan, S Archer-Hartmann, NT Supekar… - …, 2021 - academic.oup.com
The emergence of the coronavirus disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created the need for …

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade

J Vandooren, PE Van den Steen… - Critical reviews in …, 2013 - Taylor & Francis
Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Multifaceted computational modeling in glycoscience

S Perez, O Makshakova - Chemical Reviews, 2022 - ACS Publications
Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

Myocardial extracellular matrix: an ever-changing and diverse entity

M Rienks, AP Papageorgiou… - Circulation …, 2014 - ahajournals.org
The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …

The challenge and promise of glycomics

RD Cummings, JM Pierce - Chemistry & biology, 2014 - cell.com
Glycomics is a broad and emerging scientific discipline focused on defining the structures
and functional roles of glycans in biological systems. The staggering complexity of the …

Effects of N-glycosylation on protein conformation and dynamics: Protein Data Bank analysis and molecular dynamics simulation study

HS Lee, Y Qi, W Im - Scientific reports, 2015 - nature.com
N-linked glycosylation is one of the most important, chemically complex and ubiquitous post-
translational modifications in all eukaryotes. The N-glycans that are covalently linked to …

The impact of glycosylation on the biological function and structure of human immunoglobulins

JN Arnold, MR Wormald, RB Sim, PM Rudd… - Annu. Rev …, 2007 - annualreviews.org
Immunoglobulins are the major secretory products of the adaptive immune system. Each is
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …