Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology

MCK Leung, PL Williams, A Benedetto… - Toxicological …, 2008 - academic.oup.com
The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …

Pharmacological approaches to restore mitochondrial function

PA Andreux, RH Houtkooper, J Auwerx - Nature reviews Drug …, 2013 - nature.com
Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but
also implicated in age-related diseases, including those that affect the metabolic and …

Seaweed extract stimuli in plant science and agriculture

JS Craigie - Journal of applied phycology, 2011 - Springer
Both micro-and macroalgae have long been used to augment plant productivity and food
production in various regions of the world through their beneficial effects when applied to …

Caenorhabditis elegans is a useful model for anthelmintic discovery

AR Burns, GM Luciani, G Musso, R Bagg, M Yeo… - Nature …, 2015 - nature.com
Parasitic nematodes infect one quarter of the world's population and impact all humans
through widespread infection of crops and livestock. Resistance to current anthelmintics has …

High‐throughput screening and small animal models, where are we?

J Giacomotto, L Ségalat - British journal of pharmacology, 2010 - Wiley Online Library
Current high‐throughput screening methods for drug discovery rely on the existence of
targets. Moreover, most of the hits generated during screenings turn out to be invalid after …

An enhanced C. elegans based platform for toxicity assessment

H **ong, C Pears, A Woollard - Scientific reports, 2017 - nature.com
There is a well-defined regulatory framework governing the approval of chemicals for use as
pharmaceuticals or release into the environment. Toxicity assessment is thus a major hurdle …

A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity

HT Shanley, AC Taki, JJ Byrne, N Nguyen… - Parasites & …, 2024 - Springer
Background Infection with parasitic nematodes (helminths), particularly those of the order
Strongylida (such as Haemonchus contortus), can cause significant and burdensome …

Selective control of parasitic nematodes using bioactivated nematicides

AR Burns, RJ Baker, M Kitner, J Knox, B Cooke… - Nature, 2023 - nature.com
Parasitic nematodes are a major threat to global food security, particularly as the world
amasses 10 billion people amid limited arable land,,–. Most traditional nematicides have …

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

AR Burns, IM Wallace, J Wildenhain, M Tyers… - Nature chemical …, 2010 - nature.com
The resistance of Caenorhabditis elegans to pharmacological perturbation limits its use as a
screening tool for novel small bioactive molecules. One strategy to improve the hit rate of …

Agricultural functions and action mechanisms of plant biostimulants (PBs) an introduction

P du Jardin, L Xu, D Geelen - The chemical biology of plant …, 2020 - Wiley Online Library
The concept of biostimulant has gained an increasing interest in plant science. Biostimulants
are not providing nutrients as their primary function, as opposed to fertilizers, and they do not …