Hippocampal GABAergic inhibitory interneurons

KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Reinventing radiobiology in the light of FLASH radiotherapy

CL Limoli, MC Vozenin - Annual Review of Cancer Biology, 2023 - annualreviews.org
Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …

Ionizing radiation-induced immune and inflammatory reactions in the brain

K Lumniczky, T Szatmári, G Sáfrány - Frontiers in immunology, 2017 - frontiersin.org
Radiation-induced late brain injury consisting of vascular abnormalities, demyelination,
white matter necrosis, and cognitive impairment has been described in patients subjected to …

Challenges to the central nervous system during human spaceflight missions to Mars

GR Clément, RD Boyle, KA George… - Journal of …, 2020 - journals.physiology.org
Space travel presents a number of environmental challenges to the central nervous system,
including changes in gravitational acceleration that alter the terrestrial synergies between …

Neuro-consequences of the spaceflight environment

SD Mhatre, J Iyer, S Puukila, AM Paul… - Neuroscience & …, 2022 - Elsevier
As human space exploration advances to establish a permanent presence beyond the Low
Earth Orbit (LEO) with NASA's Artemis mission, researchers are striving to understand and …

New concerns for neurocognitive function during deep space exposures to chronic, low dose-rate, neutron radiation

MM Acharya, JE Baulch, PM Klein, DB Al Anoud… - Eneuro, 2019 - eneuro.org
As NASA prepares for a mission to Mars, concerns regarding the health risks associated
with deep space radiation exposure have emerged. Until now, the impacts of such …

Persistent nature of alterations in cognition and neuronal circuit excitability after exposure to simulated cosmic radiation in mice

VK Parihar, M Maroso, A Syage, BD Allen… - Experimental …, 2018 - Elsevier
Of the many perils associated with deep space travel to Mars, neurocognitive complications
associated with cosmic radiation exposure are of particular concern. Despite these …

[HTML][HTML] Behavioral effects of space radiation: A comprehensive review of animal studies

F Kiffer, M Boerma, A Allen - Life sciences in space research, 2019 - Elsevier
As NASA prepares for the first manned mission to Mars in the next 20 years, close attention
has been placed on the cognitive welfare of astronauts, who will likely endure extended …

Elucidating the neurological mechanism of the FLASH effect in juvenile mice exposed to hypofractionated radiotherapy

BD Allen, Y Alaghband, EA Kramár, N Ru… - Neuro …, 2023 - academic.oup.com
Background Ultrahigh dose-rate radiotherapy (FLASH-RT) affords improvements in the
therapeutic index by minimizing normal tissue toxicities without compromising antitumor …

Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments

Y Alaghband, PM Klein, EA Kramár… - Cellular and Molecular …, 2023 - Springer
Technological advancements have facilitated the implementation of realistic, terrestrial-
based complex 33-beam galactic cosmic radiation simulations (GCR Sim) to now probe …