Pleiotropic effects of GLP-1 and analogs on cell signaling, metabolism, and function
J Rowlands, J Heng, P Newsholme… - Frontiers in …, 2018 - frontiersin.org
The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its “incretin effect”
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …
[HTML][HTML] The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
D Athauda, T Foltynie - Drug discovery today, 2016 - Elsevier
Highlights•GLP-1 analogs can cross the blood–brain barrier and stimulate the GLP-1
receptor in the brain.•Stimulation of the GLP-1 receptor has shown effects on mitochondrial …
receptor in the brain.•Stimulation of the GLP-1 receptor has shown effects on mitochondrial …
Utility of neuronal-derived exosomes to examine molecular mechanisms that affect motor function in patients with Parkinson disease: a secondary analysis of the …
Importance Exenatide, a glucagon-like peptide 1 agonist used in type 2 diabetes, was
recently found to have beneficial effects on motor function in a randomized, placebo …
recently found to have beneficial effects on motor function in a randomized, placebo …
GIP and GLP‐1, the two incretin hormones: similarities and differences
Y Seino, M Fukushima, D Yabe - Journal of diabetes …, 2010 - Wiley Online Library
Gastric inhibitory polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are the two
primary incretin hormones secreted from the intestine on ingestion of glucose or nutrients to …
primary incretin hormones secreted from the intestine on ingestion of glucose or nutrients to …
Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells
YS Lee, HS Jun - Metabolism, 2014 - Elsevier
Abstract Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released from intestinal L-
cells in response to nutrients. GLP-1 lowers blood glucose levels by stimulating insulin …
cells in response to nutrients. GLP-1 lowers blood glucose levels by stimulating insulin …
GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes
Type 1 diabetes (T1D) is an autoimmune disease characterized by insulitis and islet β-cell
loss. Thus, an effective therapy may require β-cell restoration and immune suppression …
loss. Thus, an effective therapy may require β-cell restoration and immune suppression …
Regulation of glucose homeostasis by GLP-1
P Nadkarni, OG Chepurny, GG Holz - Progress in molecular biology and …, 2014 - Elsevier
Abstract Glucagon-like peptide-1 (7–36) amide (GLP-1) is a secreted peptide that acts as a
key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric …
key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric …
Mechanisms of action of glucagon-like peptide 1 in the pancreas
ME Doyle, JM Egan - Pharmacology & therapeutics, 2007 - Elsevier
Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …
Effects of glucagon-like peptide-1 on oxidative stress and Nrf2 signaling
YS Oh, HS Jun - International journal of molecular sciences, 2017 - mdpi.com
Oxidative cellular damage caused by free radicals is known to contribute to the
pathogenesis of various diseases such as cancer, diabetes, and neurodegenerative …
pathogenesis of various diseases such as cancer, diabetes, and neurodegenerative …
GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress
Perturbation of endoplasmic reticulum (ER) homeostasis impairs insulin biosynthesis, β cell
survival, and glucose homeostasis. We show that a murine model of diabetes is associated …
survival, and glucose homeostasis. We show that a murine model of diabetes is associated …