Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …

The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …

Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1)
blockade in cancer patients, but the mechanisms underlying their immunosuppressive …

Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading
cause of cognitive impairment, the mechanisms of which remain poorly understood. In the …

Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

While intestinal Th17 cells are critical for maintaining tissue homeostasis, recent studies
have implicated their roles in the development of extra-intestinal autoimmune diseases …

Background: High blood pressure (BP) continues to be a major, poorly controlled but
modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet …

BACKGROUND Blood and lymphatic vessel networks form two arms of the vertebrate
cardiovascular system that play complementary roles in body homeostasis maintenance and …

Accumulating evidence indicates that gut microorganisms have a pathogenic role in
autoimmune diseases, including in multiple sclerosis. Studies of experimental autoimmune …

The pathogenesis of hypertension is known to involve a diverse range of contributing factors
including genetic, environmental, hormonal, hemodynamic and inflammatory forces, to …