Multiscale computational models of complex biological systems
Integration of data across spatial, temporal, and functional scales is a primary focus of
biomedical engineering efforts. The advent of powerful computing platforms, coupled with …
biomedical engineering efforts. The advent of powerful computing platforms, coupled with …
Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias
S Dhein, T Seidel, A Salameh, J Jozwiak… - Frontiers in …, 2014 - frontiersin.org
Coordinated electrical activation of the heart is essential for the maintenance of a regular
cardiac rhythm and effective contractions. Action potentials spread from one cell to the next …
cardiac rhythm and effective contractions. Action potentials spread from one cell to the next …
A cell-based framework for numerical modeling of electrical conduction in cardiac tissue
In this paper, we study a mathematical model of cardiac tissue based on explicit
representation of individual cells. In this EMI model, the extracellular (E) space, the cell …
representation of individual cells. In this EMI model, the extracellular (E) space, the cell …
Properties of cardiac conduction in a cell-based computational model
The conduction of electrical signals through cardiac tissue is essential for maintaining the
function of the heart, and conduction abnormalities are known to potentially lead to life …
function of the heart, and conduction abnormalities are known to potentially lead to life …
Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells
Human embryonic stem cells have emerged as the prototypical source from which
cardiomyocytes can be derived for use in drug discovery and cell therapy. However, such …
cardiomyocytes can be derived for use in drug discovery and cell therapy. However, such …
Noncoding RNA network crosstalk in organ fibrosis
H Ling, XC Wang, ZY Liu, S Mao, JJ Yang, JM Sha… - Cellular signalling, 2024 - Elsevier
Fibrosis is a process involving excessive accumulation of extracellular matrix components,
the severity of which interferes with the function of the organ in question. With the advances …
the severity of which interferes with the function of the organ in question. With the advances …
A potential role for integrin signaling in mechanoelectrical feedback
Certain forms of heart disease involve gross morphological changes to the myocardium that
alter its hemodynamic loading conditions. These changes can ultimately lead to the …
alter its hemodynamic loading conditions. These changes can ultimately lead to the …
Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue
Ectopic heartbeats can trigger reentrant arrhythmias, leading to ventricular fibrillation and
sudden cardiac death. Such events have been attributed to perturbed Ca2+ handling in …
sudden cardiac death. Such events have been attributed to perturbed Ca2+ handling in …
Circular RNAs in organ fibrosis
J Yao, Q Dai, Z Liu, L Zhou, J Xu - Circular RNAs: Biogenesis and …, 2018 - Springer
Fibrosis refers to a process involving the accumulation of extracellular matrix components. It
could happen in chronic organ injury or during the recovery of acute organ injury. The …
could happen in chronic organ injury or during the recovery of acute organ injury. The …
A three-dimensional continuum model of active contraction in single cardiomyocytes
We investigate the interaction of intracellular calcium spatio-temporal variations with the self-
sustained contractions in cardiac myocytes. A 3D continuum mathematical model is …
sustained contractions in cardiac myocytes. A 3D continuum mathematical model is …