Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

Transgenerational epigenetic inheritance in mammals remains a debated subject. Here, we
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …

The gut microbiota operates at the interface of host–environment interactions to influence
human homoeostasis and metabolic networks,,–. Environmental factors that unbalance gut …

Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …

It is well-established that testicular spermatozoa are immature and acquire motility and
fertilization capabilities during transit throughout the epididymis. The epididymis is a duct …

Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

Increasing evidence indicates that metabolic disorders in offspring can result from the
father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat …

Several recent studies link parental environments to phenotypes in subsequent generations.
In this work, we investigate the mechanism by which paternal diet affects offspring …