Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Environmental exposure is an important but underappreciated risk factor contributing to the
development and severity of cardiovascular disease (CVD). The heart and vascular system …

Childhood adversity, characterized by abuse, neglect, and household dysfunction, is a
problem that exerts a significant impact on individuals, families, and society. Growing …

Angiogenesis plays an important role in physiological bone growth and remodeling, as well
as in pathological bone disorders such as fracture repair, osteonecrosis, and tumor …

G protein-coupled receptors (GPCRs), such as β-adrenergic and angiotensin II receptors,
located in the membranes of all three major cardiac cell types, ie myocytes, fibroblasts and …

The endothelin (ET) system consists of two G protein coupled–receptors (GPCRs), ET type A
receptor (ETAR) and ET type B receptor (ETBR), and three endogenous ligands, ET-1, ET-2 …

Since the introduction of the 45S5-bioactive glass (BG), numerous new BG compositions
have been developed. Compared to the 45S5-BG, 1393-BG shows favorable processing …

Hypertension represents one of the primary and most common risk factors leading to the
development of heart failure (HF) across the entire spectrum of left ventricular ejection …

Background: Patients with colorectal cancer (CRC) often present with dyspnea and fatigue.
These are also frequent symptoms in patients with chronic heart failure (CHF). Objectives …

Growing evidence suggests that adverse childhood experiences (ACEs) increase the risks
for coronary heart disease and hypertension in mid and late adulthood. We previously …