Basic mechanisms of diabetic heart disease
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy
G Jia, VG DeMarco, JR Sowers - Nature Reviews Endocrinology, 2016 - nature.com
Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote
the development of a specific form of cardiomyopathy that is independent of coronary artery …
the development of a specific form of cardiomyopathy that is independent of coronary artery …
Molecular mechanisms of diabetic cardiomyopathy
In recent years, diabetes mellitus has become an epidemic and now represents one of the
most prevalent disorders. Cardiovascular complications are the major cause of mortality and …
most prevalent disorders. Cardiovascular complications are the major cause of mortality and …
Functional screening identifies miRNAs inducing cardiac regeneration
A Eulalio, M Mano, MD Ferro, L Zentilin, G Sinagra… - Nature, 2012 - nature.com
In mammals, enlargement of the heart during embryonic development is primarily
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways
Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …
population. Both experimental and clinical evidence suggest that diabetic subjects are …
Diabetic cardiomyopathy: current and future therapies. Beyond glycemic control
G Borghetti, D Von Lewinski, DM Eaton… - Frontiers in …, 2018 - frontiersin.org
Diabetes mellitus and the associated complications represent a global burden on human
health and economics. Cardiovascular diseases are the leading cause of death in diabetic …
health and economics. Cardiovascular diseases are the leading cause of death in diabetic …
[HTML][HTML] Diabetic cardiomyopathy: where we are and where we are going
WS Lee, J Kim - The Korean journal of internal medicine, 2017 - ncbi.nlm.nih.gov
The global burden of diabetes mellitus and its related complications are currently increasing.
Diabetes mellitus affects the heart through various mechanisms including microvascular …
Diabetes mellitus affects the heart through various mechanisms including microvascular …
Role of microRNAs in diabetes and its cardiovascular complications
Diabetes is the most common metabolic disorder and is recognized as one of the most
important health threats of our time. MicroRNAs (miRNAs) are a novel group of non-coding …
important health threats of our time. MicroRNAs (miRNAs) are a novel group of non-coding …
MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway
Y Kuwabara, T Horie, O Baba, S Watanabe… - Circulation …, 2015 - Am Heart Assoc
Rationale: In some patients with type 2 diabetes mellitus (DM) without hypertension, cardiac
hypertrophy and attenuated cardiac function are observed, and this insult is termed diabetic …
hypertrophy and attenuated cardiac function are observed, and this insult is termed diabetic …
The eNOS signalosome and its link to endothelial dysfunction
M Siragusa, I Fleming - Pflügers Archiv-European Journal of Physiology, 2016 - Springer
Endothelial nitric oxide synthase (eNOS) plays an essential role in the regulation of
endothelial function and acts as a master regulator of vascular tone and homeostasis …
endothelial function and acts as a master regulator of vascular tone and homeostasis …