d-Amino acids: new clinical pathways for brain diseases

IN de Oliveira Souza, R Roychaudhuri… - Trends in Molecular …, 2023 - cell.com
Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …

d‐Amino acids in biological systems

S Du, M Wey, DW Armstrong - Chirality, 2023 - Wiley Online Library
Investigations on the occurrence and biochemical roles of free D‐amino acids and D‐amino
acid‐containing peptides and proteins in living systems have increased in frequency and …

Bisphenol F induces liver-gut alteration in zebrafish

H Wang, S Qi, X Mu, L Yuan, Y Li, J Qiu - Science of The Total Environment, 2022 - Elsevier
The unease of consumers with bisphenol A has led to the increased industrial usage of
bisphenol F (BPF), which is a new hazard to environmental health. Here, zebrafish were …

L‐serine: a neglected amino acid with a potential therapeutic role in diabetes

LJ Holm, K Buschard - Apmis, 2019 - Wiley Online Library
L‐serine is classified as a non‐essential amino acid; however, L‐serine is indispensable
having a central role in a broad range of cellular processes. Growing evidence suggests a …

d-Alanine: Distribution, origin, physiological relevance, and implications in disease

CJ Lee, TA Qiu, JV Sweedler - … et Biophysica Acta (BBA)-Proteins and …, 2020 - Elsevier
Abstract d-Alanine (d-Ala) is an unusual endogenous amino acid present in invertebrates
and vertebrates. Compared to its l-isomer, the characterization of d-Ala is challenging …

New therapeutic targets and drugs for schizophrenia beyond dopamine D2 receptor antagonists

A Peng, J Chai, H Wu, B Bai, H Yang… - Neuropsychiatric …, 2024 - Taylor & Francis
Schizophrenia is a disease with a complex pathological mechanism that is influenced by
multiple genes. The study of its pathogenesis is dominated by the dopamine hypothesis, as …

d-Amino acids in mammalian endocrine tissues

G Chieffi Baccari, S Falvo, A Santillo… - Amino Acids, 2020 - Springer
Abstract d-Aspartate, d-serine and d-alanine are a regular occurrence in mammalian
endocrine tissues, though in amounts varying with the type of gland. The pituitary gland …

Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

L Suwandhi, I Altun, R Karlina, V Miok… - Nature …, 2021 - nature.com
Adipose tissue expansion, as seen in obesity, is often metabolically detrimental causing
insulin resistance and the metabolic syndrome. However, white adipose tissue expansion at …

The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance

RÅ Jersin, LR Jonassen, SN Dankel - Frontiers in cell and …, 2022 - frontiersin.org
Obesity, insulin resistance and type 2 diabetes represent major global health challenges,
and a better mechanistic understanding of the altered metabolism in these conditions may …

[HTML][HTML] Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia

R Okubo, M Okada, E Motomura - Biomolecules, 2024 - mdpi.com
For several decades, the dopamine hypothesis contributed to the discovery of numerous
typical and atypical antipsychotics and was the sole hypothesis for the pathophysiology of …