Amyotrophic lateral sclerosis (ALS) is a devastating progressive motor neuron disease that
affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought …

Small GTPases are central regulators of many cellular processes. The highly conserved Rap
GTPases perform essential functions in the mammalian nervous system during development …

Rationale Antipsychotic-induced parkinsonism (AIP) is a severe adverse affect of neuroleptic
treatment. Interindividual heterogeneity in AIP development and severity is associated with …

Background Idiopathic epilepsy (IE) is a common neurological disorder in the domestic dog,
and is defined as repeated seizure activity having no identifiable underlying cause. Some …

An idiopathic epilepsy (IE) risk haplotype on canine chromosome (CFA) 14 has been
reported to interact with the CFA37 common risk haplotype in the Belgian shepherd (BS) …

Because abnormal development of striatal neurons is thought to be the part of pathology
underlying major psychiatric illnesses, we studied the expression pattern of genes involved …

Idiopathic epilepsy (IE) has been known to be inherited in the Belgian Tervuren for many
decades. Risk genotypes for IE in this breed have recently been identified on Canis …

Background: Idiopathic epilepsy (IE) disproportionately affects Belgian shepherd dogs and
although genomic risk markers have been identified previously in the breed, causative …

The kinase non-catalytic c-lobe domain (KIND) evolved from the catalytic protein kinase fold
into a potential protein interaction module for signalling proteins. Spir family actin organizers …

In the rodent forebrain GABAergic neurons are generated from progenitor cells that express
the transcription factors Dlx1 and Dlx2. The Rap-1 guanine nucleotide exchange factor, MR …