Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases

G Li, T Chen, J Dahlman… - Journal of …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids,
proteins, lipids and metabolites that play versatile roles in intercellular and interorgan …

Harmonising cellular conversations: decoding the vital roles of extracellular vesicles in respiratory system intercellular communications

B Jadamba, Y **, H Lee - European Respiratory Review, 2024 - publications.ersnet.org
Extracellular vesicles (EVs) released by various cells play crucial roles in intercellular
communication within the respiratory system. This review explores the historical context and …

MicroRNA-212-5p, an anti-proliferative miRNA, attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents

T Chen, MR Sun, Q Zhou, AM Guzman… - … Therapy-Nucleic Acids, 2022 - cell.com
MicroRNAs (miRNA, miR-) play important roles in disease development. In this study, we
identified an anti-proliferative miRNA, miR-212-5p, that is induced in pulmonary artery …

[HTML][HTML] Insight into endothelial cell-derived extracellular vesicles in cardiovascular disease: molecular mechanisms and clinical implications

X Wang, B He - Pharmacological Research, 2024 - Elsevier
The endothelium is crucial in regulating vascular function. Extracellular vesicles (EVs) serve
as membranous structures released by cells to facilitate intercellular communication through …

A Machine Learning Model Based on microRNAs for the Diagnosis of Essential Hypertension

A Jusic, I Junuzovic, A Hujdurovic, L Zhang, M Vausort… - Non-coding RNA, 2023 - mdpi.com
Introduction: Hypertension is a major and modifiable risk factor for cardiovascular diseases.
Essential, primary, or idiopathic hypertension accounts for 90–95% of all cases. Identifying …

Extracellular vesicles in pulmonary hypertension: a dangerous liaison?

M Conti, M Minniti, M Tiné, M De Francesco, R Gaeta… - Biology, 2023 - mdpi.com
Simple Summary This review discusses the role of extracellular vesicles in pulmonary
hypertension a serious and progressive lung disease characterized by high blood pressure …

Emerging role of exosomes in vascular diseases

Y Ren, H Zhang - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Exosomes are biological small spherical lipid bilayer vesicles secreted by most cells in the
body. Their contents include nucleic acids, proteins, and lipids. Exosomes can transfer …

Extracellular vesicles in venous thromboembolism and pulmonary hypertension

J Zhang, X Hu, T Wang, R **ao, L Zhu, M Ruiz… - Journal of …, 2023 - Springer
Venous thromboembolism (VTE) is a multifactorial disease, and pulmonary hypertension
(PH) is a serious condition characterized by pulmonary vascular remodeling leading with …

Tadalafil Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells-Derived Exosomes in Pulmonary Hypertension by Upregulating miR-29a-3p

Y Liu, C He, Q Zhong, X Shi, H Li, G Fu… - International Journal …, 2024 - Taylor & Francis
Introduction Pulmonary hypertension (PH) is a progressive and life-threatening condition.
Recent research has demonstrated that exosomes derived from mesenchymal stem cells …

Roles and Potential Mechanisms of Endothelial Cell-Derived Extracellular Vesicles in Ischemic Stroke

X Yu, Y Huang, C Li - Translational Stroke Research, 2025 - Springer
The etiology and mechanisms of ischemic stroke are complex, encompassing a variety of
pathological processes including atherosclerosis, energy failure, neuroinflammation, blood …