Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

This Review emphasizes the impact of APOE4—the most significant genetic risk factor for
Alzheimer's disease (AD)—on peripheral and neural effects starting in childhood. We …

The human brain demonstrates structural and functional asymmetries which have
implications for ageing and mental and neurological disease development. We used a set of …

Across the lifespan, the human body and brain endure the impact of a plethora of
exogenous and endogenous factors that determine the health outcome in old age. The …

Age-related cognitive decline is a global phenomenon that affects individuals worldwide.
The course and extent of this decline are influenced by numerous factors, such as genetics …

Background The temporal relationships across cardiometabolic diseases (CMDs) were
recently conceptualized as the cardiometabolic continuum (CMC), sequence of …

Brain age refers to age predicted by brain features. Brain age has previously been
associated with various health and disease outcomes and suggested as a potential …

Obesity represents a significant public health concern and is linked to various comorbidities
and cognitive impairments. Previous research indicates that elevated body mass index (BMI) …

Aim To examine the associations between visceral adipose tissue (VAT) and brain structural
measures at midlife and explore how these associations may be affected by age, sex and …

Introduction The menopause transition is associated with several cardiometabolic risk
factors. Poor cardiometabolic health is further linked to microvascular brain lesions, which …