CD39 and CD73 in immunity and inflammation
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration,
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …
Cellular function and molecular structure of ecto-nucleotidases
Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
[HTML][HTML] Nucleotide-and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade
GG Yegutkin - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2008 - Elsevier
The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …
responses has long been known and appreciated, but the integrative view of purinergic …
Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
MJL Bours, ELR Swennen, F Di Virgilio… - Pharmacology & …, 2006 - Elsevier
Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …
The immune system is occupied with protecting the host against such dangers in order to …
Hypoxia-inducible factor 1 and cardiovascular disease
GL Semenza - Annual review of physiology, 2014 - annualreviews.org
Cardiac function is required for blood circulation and systemic oxygen delivery. However,
the heart has intrinsic oxygen demands that must be met to maintain effective contractility …
the heart has intrinsic oxygen demands that must be met to maintain effective contractility …
The cAMP pathway as therapeutic target in autoimmune and inflammatory diseases
VK Raker, C Becker, K Steinbrink - Frontiers in immunology, 2016 - frontiersin.org
Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the
immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent …
immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent …
[HTML][HTML] Targeting CD73 to augment cancer immunotherapy
M Roh, DA Wainwright, JD Wu, Y Wan… - Current opinion in …, 2020 - Elsevier
Highlights•CD73 is a multifunctional ectoenzyme affecting both tumor cells and immune
cells.•CD73 has been hijacked by TME to promote tumor growth and metastasis.•Targeting …
cells.•CD73 has been hijacked by TME to promote tumor growth and metastasis.•Targeting …
Physiological roles for ecto-5'-nucleotidase (CD73)
Nucleotides and nucleosides influence nearly every aspect of physiology and
pathophysiology. Extracellular nucleotides are metabolized through regulated …
pathophysiology. Extracellular nucleotides are metabolized through regulated …
NT5E Mutations and Arterial Calcifications
C St. Hilaire, SG Ziegler, TC Markello… - … England Journal of …, 2011 - Mass Medical Soc
Background Arterial calcifications are associated with increased cardiovascular risk, but the
genetic basis of this association is unclear. Methods We performed clinical, radiographic …
genetic basis of this association is unclear. Methods We performed clinical, radiographic …
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities
GG Yegutkin - Critical reviews in biochemistry and molecular …, 2014 - Taylor & Francis
Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …
organs and tissues. Most models of purinergic signaling depend on functional interactions …