Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Integrins are a family of α/β heterodimeric adhesion metalloprotein receptors and their
functions are highly dependent on and regulated by different divalent cations. Recently …

It is widely believed that rolling lymphocytes require successive chemokine-induced
signaling for lymphocyte function–associated antigen 1 (LFA-1) to achieve a threshold …

Integrins are cell adhesion molecules that play critical roles in development, wound healing,
hemostasis, immunity and cancer. Advances in the past two years have shed light on the …

We used negative stain electron microscopy (EM) to examine the conformational changes in
the ectodomains required for activation of the leukocyte integrins α X β 2 and α L β 2. They …

Integrins comprise a large family of cell-cell and cell-matrix adhesion receptors that rapidly
modulate their adhesiveness. The arrest of leukocyte integrins on target vascular beds …

We report the structure of an integrin with an αI domain, αXβ2, the complement receptor type
4. It was earlier expected that a fixed orientation between the αI domain and the β‐propeller …

Leucocytes are highly motile cells. Their ability to migrate into tissues and organs is
dependent on cell adhesion molecules. The integrins are a family of heterodimeric …

The movement of leukocytes from the blood into peripheral tissues plays a key role in
immunity as well as chronic inflammatory and autoimmune diseases. The shear force of …

How the integrin head transitions to the high-affinity conformation is debated. Although
experiments link activation with the opening of the hinge angle between the βA and hybrid …