Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …

Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Overcoming anticancer drug resistance is a major challenge in cancer therapy, requiring
innovative strategies that consider the extensive tumor heterogeneity and adaptability. We …

l-asparaginase (ASNase, EC 3.5. 1.1) is an aminohydrolase enzyme with important uses in
the therapeutic/pharmaceutical and food industries. Its main applications are as an …

Cancer cells rely on certain extracellular nutrients to sustain their metabolism and growth.
Solute carrier (SLC) transporters enable cells to acquire extracellular nutrients or shuttle …

TP53 tumor suppressor is frequently altered in lethal, castration-resistant prostate cancer
(CRPC). However, to date there are no effective treatments that specifically target TP53 …

Malignant cells often demonstrate a proliferative advantage when compared to non-
malignant cells. However, the rapid growth and metabolism required for survival can also …

Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial
cells undergo a reversible phenotype switch via the loss of adhesion capacity and …

Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral
infections. Metabolic reprogramming provides the cell with energy and biomass for large …

The importance of fatty acid (FA) metabolism in cancer is well-established, yet the
mechanisms underlying metabolic reprogramming remain elusive. Here, we identify …