Viruses pose a serious threat to human health and society in general, as virus infections are
one of the main causes of morbidity and mortality. Till May 2022, over 513 million people …

Metabolic glycoengineering (MGE) is a technique for manipulating cellular metabolism to
modulate glycosylation. MGE is used to increase the levels of natural glycans and, more …

Several novel anti-influenza compounds are in various phases of clinical development. One
of these, T-705 (favipiravir), has a mechanism of action that is not fully understood but is …

To date, more than 17 million cases of coronavirus disease 2019 (COVID-19) and 900,000
deaths have been reported globally (World Health Organization, 2020). Major collaborative …

Influenza is a long-standing health problem. For treatment of seasonal flu and possible
pandemic infections, there is a need to develop new anti-influenza drugs that have good …

Objectives The recent viral pandemic poses a unique challenge for healthcare providers.
Despite the remarkable progress, the number of novel antiviral agents in the pipeline is …

Influenza therapeutics with new targets and mechanisms of action are urgently needed to
combat potential pandemics, emerging viruses, and constantly mutating strains in …

The world had been anticipating another influenza pandemic since the last one in 1968. The
pandemic influenza A H1N1 2009 virus (A/2009/H1N1) finally arrived, causing the first …

Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging
respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral …