Transposable elements in mammalian chromatin organization
Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …
mammalian genomic sequence. TEs are capable of making additional copies of themselves …
The relationship between genome structure and function
Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …
regulatory elements: promoters, enhancers and boundary elements. During differentiation …
Transcription factors and 3D genome conformation in cell-fate decisions
How cells adopt different identities has long fascinated biologists. Signal transduction in
response to environmental cues results in the activation of transcription factors that …
response to environmental cues results in the activation of transcription factors that …
Structural variation in the 3D genome
Structural and quantitative chromosomal rearrangements, collectively referred to as
structural variation (SV), contribute to a large extent to the genetic diversity of the human …
structural variation (SV), contribute to a large extent to the genetic diversity of the human …
Stimuli-responsive drug delivery systems triggered by intracellular or subcellular microenvironments
T Sun, C Jiang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Drug delivery systems (DDS) triggered by local microenvironment represents the state-of-art
of nanomedicine design, where the triggering hallmarks at intracellular and subcellular …
of nanomedicine design, where the triggering hallmarks at intracellular and subcellular …
Three-dimensional genome structures of single diploid human cells
The 3D genome as moderator of chromosomal communication
Proper expression of genes requires communication with their regulatory elements that can
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …