Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …

Importance In communities with high rates of coronavirus disease 2019, reports have
emerged of children with an unusual syndrome of fever and inflammation. Objectives To …

Neutrophils are best known for their critical role in host defense, for which they utilize
multiple innate immune mechanisms, including microbe-associated pattern recognition …

Biological molecules are increasingly becoming a part of the therapeutics portfolio that has
been either recently approved for marketing or those that are in the pipeline of several …

Monocytes undergo phenotypic and functional changes in response to inflammatory cues,
but the molecular signals that drive different monocyte states remain largely undefined. We …

Vascular pathologies underpin and intertwine autoimmune rheumatic diseases and
cardiovascular conditions, and atherosclerosis is increasingly recognized as the leading …

Fibrotic disorders account for an increasing burden of disease-associated morbidity and
mortality worldwide. Although numerous risk factors have been recognized, the etiologies of …

Small immune complexes cause type III hypersensitivity reactions that frequently result in
tissue injury. The responsible mechanisms, however, remain unclear and differ depending …

Heparin-induced thrombocytopenia (HIT) is an immune-mediated thrombocytopenic
disorder associated with a severe prothrombotic state. We investigated whether neutrophils …