Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration,
primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed …

The platelet-derived growth factor (PDFG) signaling pathway exerts persistent activation in
response to a variety of stimuli and facilitates the progression of hepatic fibrosis. Since this …

Vascular pericytes, an important cellular component in the tumor microenvironment, are
often associated with tumor vasculatures, and their functions in cancer invasion and …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

Many tumors produce platelet-derived growth factor (PDGF)-DD, which promotes cellular
proliferation, epithelial-mesenchymal transition, stromal reaction, and angiogenesis through …

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …

The advent of in vitro DNA amplification has enabled rapid acquisition of genomic
information. We present here an analogous technique for protein detection, in which the …

Bioinformatic analysis can not only accelerate drug target identification and drug candidate
screening and refinement, but also facilitate characterization of side effects and predict drug …

Platelet-derived growth factors (PDGFs) were discovered more than two decades ago.
Today the PDGF family of growth factors consists of five different disulphide-linked dimers …

Progression of pulmonary hypertension is associated with increased proliferation and
migration of pulmonary vascular smooth muscle cells. PDGF is a potent mitogen and …