Successful materials design for bone-tissue engineering requires an understanding of the
composition and structure of native bone tissue, as well as appropriate selection of …

Osteomyelitis is a devastating disease caused by microbial infection of bone. While the
frequency of infection following elective orthopedic surgery is low, rates of reinfection are …

The regeneration of diabetic bone defects remains challenging as the innate healing
process is impaired by glucose fluctuation, reactive oxygen species (ROS), and …

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause
chronic infections. The multifactorial nature of biofilm development and drug tolerance …

Bone‐implant‐associated infections are common after orthopedic surgery due to impaired
host immune response around the implants. In particular, when a biofilm develops, the …

In the past decade, the rapid evolution of nanotechnology has spawned many fascinating
opportunities and advances for disease diagnosis and therapy. The currently available …

Immunotherapy has emerged as an effective strategy for the prevention and treatment of a
variety of diseases, including cancer, infectious diseases, inflammatory diseases, and …

Biofilms have been related to the persistence of infections on medical implants, and these
cannot be eradicated because of the resistance of biofilm structures. Therefore, a …

Biomedical implants have been widely used in various orthopedic treatments, including total
hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern …

Infection of bone defects is a common clinical problem that negatively impacts bone repair
and may result in the development of antibiotic resistance due to the long-term use of …