The biology and function of exosomes in cancer

R Kalluri - The Journal of clinical investigation, 2016 - jci.org
Humans circulate quadrillions of exosomes at all times. Exosomes are a class of
extracellular vesicles released by all cells, with a size range of 40–150 nm and a lipid …

[HTML][HTML] The regulatory role of microRNAs in breast cancer

HY Loh, BP Norman, KS Lai, NMANA Rahman… - International journal of …, 2019 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNA molecules which function as critical post-
transcriptional gene regulators of various biological functions. Generally, miRNAs negatively …

[HTML][HTML] Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

D Ha, N Yang, V Nadithe - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Exosomes are small intracellular membrane-based vesicles with different compositions that
are involved in several biological and pathological processes. The exploitation of exosomes …

The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics

D Bautista-Sánchez, C Arriaga-Canon… - … therapy Nucleic acids, 2020 - cell.com
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene
expression via base-pairing complementarity. Their role in cancer can be related to tumor …

Biological functions and current advances in isolation and detection strategies for exosome nanovesicles

K Boriachek, MN Islam, A Möller, C Salomon… - Small, 2018 - Wiley Online Library
Abstract Exosomes are nanoscale (≈ 30–150 nm) extracellular vesicles of endocytic origin
that are shed by most types of cells and circulate in bodily fluids. Exosomes carry a specific …

Tumor-derived exosomes and their role in cancer progression

TL Whiteside - Advances in clinical chemistry, 2016 - Elsevier
Tumor cells actively produce, release, and utilize exosomes to promote tumor growth.
Mechanisms through which tumor-derived exosomes subserve the tumor are under intense …

Exosomes in cancer: small particle, big player

X Zhang, X Yuan, H Shi, L Wu, H Qian, W Xu - Journal of hematology & …, 2015 - Springer
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can
shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs …

MicroRNAs: new biomarkers for diagnosis, prognosis, therapy prediction and therapeutic tools for breast cancer

G Bertoli, C Cava, I Castiglioni - Theranostics, 2015 - pmc.ncbi.nlm.nih.gov
Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of
several human cancers, including breast cancer (BC), as strong evidence has been found …

Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications

J De Toro, L Herschlik, C Waldner… - Frontiers in …, 2015 - frontiersin.org
From the time when they were first described in the 1970s by the group of Johnstone and
Stahl, exosomes are a target of constant research. Exosomes belong to the family of …

[HTML][HTML] Methodologies to isolate and purify clinical grade extracellular vesicles for medical applications

A Akbar, F Malekian, N Baghban, SP Kodam, M Ullah - Cells, 2022 - mdpi.com
The use of extracellular vesicles (EV) in nano drug delivery has been demonstrated in many
previous studies. In this study, we discuss the sources of extracellular vesicles, including …