Ocular drug delivery: a comprehensive review

S Ahmed, MM Amin, S Sayed - AAPS PharmSciTech, 2023 - Springer
The human eye is a sophisticated organ with distinctive anatomy and physiology that
hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration …

Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

S Li, L Chen, Y Fu - Journal of nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …

[HTML][HTML] Block copolymer micelles as ocular drug delivery systems

AA Assiri, K Glover, D Mishra, D Waite, LK Vora… - Drug discovery today, 2024 - Elsevier
Highlights•Amphiphilic polymers self-assemble into block copolymer micelles in
solution.•Polymeric micelles have longer and better contact with the ocular …

Recent advances of ocular drug delivery systems: prominence of ocular implants for chronic eye diseases

M Mostafa, A Al Fatease, RG Alany, H Abdelkader - Pharmaceutics, 2023 - mdpi.com
Chronic ocular diseases can seriously impact the eyes and could potentially result in
blindness or serious vision loss. According to the most recent data from the WHO, there are …

Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo …

S Ahmed, MM Amin, SM El-Korany, S Sayed - Drug Delivery, 2022 - Taylor & Francis
The purpose of this manuscript was to develop and optimize Fenticonazole Nitrate (FTN)-
loaded novasomes aiming to enhance drug corneal penetration and to improve its …

Norfloxacin loaded nano-cubosomes for enhanced management of otitis externa: in vitro and in vivo evaluation

AM Al-Mahallawi, AA Abdelbary… - International Journal of …, 2021 - Elsevier
The research's goal is to design and formulate nano-structured cubosomes loaded with
norfloxacin (NFX) for management of otitis externa. In this study, glyceryl monooleate (GMO) …

Transdermal application of diacerin loaded-terpene enriched invasomes: an approach to augment anti-edema and nociception inhibition activity

S Ahmed, MM Farag, MA Sadek… - Journal of Liposome …, 2024 - Taylor & Francis
This study aimed to formulate diacerein loaded terpene-enriched invasomes (DCN-TINV) to
fulfill a fruitful management of osteoarthritis. A 23 factorial design was adopted, including A …

Chitosan decorated oleosomes loaded propranolol hydrochloride hydrogel repurposed for Candida albicans-vaginal infection

MA Eltabeeb, MM Abdellatif, MA El-Nabarawi… - …, 2024 - Taylor & Francis
Aim: Our investigation aims to estimate the antifungal effect of propranolol hydrochloride
(PNL). Methods: Oleosomes (OLs) were fabricated by thin-film hydration and evaluated for …

Limonene-enriched ultra-structural cubosomes to augment ocular delivery of a poorly water soluble anti-fungal drug: Fabrication, characterization, statistical …

AA Nemr, S Ahmed, IM Adel - Journal of Drug Delivery Science and …, 2024 - Elsevier
The target of this investigation was to obtain the composition of the optimized Fenticonazole
nitrate (FCN)-loaded cubosomal formula that can prolong precorneal retention, increase …

Tailoring terpesomes and leciplex for the effective ocular conveyance of moxifloxacin hydrochloride (comparative assessment): in-vitro, ex-vivo, and in-vivo evaluation

R Albash, MM Abdellatif, M Hassan… - International Journal of …, 2021 - Taylor & Francis
Aim To compare the ability of both terpesomes (TPs) and leciplex (LPs) loaded moxifloxacin
hydrochloride (MOX) for enhancing ocular drug conveyance. Methods Two separate 21.31 …