The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

The tumor microenvironment is a heterogeneous population of cells consisting of the tumor
bulk plus supporting cells. It is becoming increasingly evident that these supporting cells are …

Proper development and function of the mammalian central nervous system (CNS) depend
critically on the activity of parenchymal sentinels referred to as microglia. Although microglia …

The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …

Mammalian microRNAs (miRNAs) have recently been identified as important regulators of
gene expression, and they function by repressing specific target genes at the post …

Cancer is a systemic disease encompassing multiple components of both tumor cells
themselves and host stromal cells. It is now clear that stromal cells in the tumor …

MicroRNAs are a family of regulatory molecules involved in many physiological processes,
including differentiation and activation of cells of the immune system. We found that brain …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Differentiation of mesenchymal stem cells into a particular lineage is tightly regulated, and
malfunction of this regulation could lead to pathological consequences. Patients with …

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the
regulation of gene expression. They are involved in the fine-tuning of fundamental biological …