[HTML][HTML] The self-organizing genome: principles of genome architecture and function
T Misteli - Cell, 2020 - cell.com
Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …
genetic, biochemical, biophysical, and cell biological methods has uncovered several …
Quantitative phase imaging: recent advances and expanding potential in biomedicine
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …
Integrated spatial genomics reveals global architecture of single nuclei
Identifying the relationships between chromosome structures, nuclear bodies, chromatin
states and gene expression is an overarching goal of nuclear-organization studies …
states and gene expression is an overarching goal of nuclear-organization studies …
Heterochromatin drives compartmentalization of inverted and conventional nuclei
The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic
and inactive heterochromatic regions of the genome,. In conventional nuclei, microscopy …
and inactive heterochromatic regions of the genome,. In conventional nuclei, microscopy …
Lamina-associated domains: links with chromosome architecture, heterochromatin, and gene repression
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …
Heterochromatin: guardian of the genome
Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …
Three-dimensional genome structures of single diploid human cells
L Tan, D ** the spatial organization of the genome
The spatial organization of the genome into compartments and topologically associated
domains can have an important role in the regulation of gene expression. But could gene …
domains can have an important role in the regulation of gene expression. But could gene …
Single-cell nuclear architecture across cell types in the mouse brain
Diverse cell types in tissues have distinct gene expression programs, chromatin states, and
nuclear architectures. To correlate such multimodal information across thousands of single …
nuclear architectures. To correlate such multimodal information across thousands of single …