The inositol trisphosphate/calcium signaling pathway in health and disease
MJ Berridge - Physiological reviews, 2016 - journals.physiology.org
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
Polyglutamine spinocerebellar ataxias—from genes to potential treatments
The dominantly inherited spinocerebellar ataxias (SCAs) are a large and diverse group of
neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and …
neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and …
Genetic variability in the regulation of gene expression in ten regions of the human brain
Germ-line genetic control of gene expression occurs via expression quantitative trait loci
(eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions …
(eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions …
[HTML][HTML] Antioxidant-based medicinal properties of stingless bee products: recent progress and future directions
Stingless bees are a type of honey producers that commonly live in tropical countries. Their
use for honey is being abandoned due to its limited production. However, the recent …
use for honey is being abandoned due to its limited production. However, the recent …
Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits
The adult mammalian cerebellar cortex is generally assumed to have a uniform
cytoarchitecture. Differences in cerebellar function are thought to arise primarily through …
cytoarchitecture. Differences in cerebellar function are thought to arise primarily through …
New roles for the cerebellum in health and disease
The cerebellum has a well-established role in maintaining motor coordination and studies of
cerebellar learning suggest that it does this by recognizing neural patterns, which it uses to …
cerebellar learning suggest that it does this by recognizing neural patterns, which it uses to …
Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2
Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited
disorder, which is caused by a pathological expansion of a polyglutamine (polyQ) tract in the …
disorder, which is caused by a pathological expansion of a polyglutamine (polyQ) tract in the …
Calcium signalling and Alzheimer's disease
MJ Berridge - Neurochemical research, 2011 - Springer
New insights into how Ca 2+ regulates learning and memory have begun to provide clues
as to how the amyloid-dependent remodelling of neuronal Ca 2+ signalling pathways can …
as to how the amyloid-dependent remodelling of neuronal Ca 2+ signalling pathways can …
Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias
Intensive scientific research devoted in the recent years to understand the molecular
mechanisms or neurodegeneration in spinocerebellar ataxias (SCAs) are identifying new …
mechanisms or neurodegeneration in spinocerebellar ataxias (SCAs) are identifying new …
Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders
Copy-number variants (CNVs) are a major contributor to the pathophysiology of autism
spectrum disorders (ASDs), but the functional impact of CNVs remains largely unexplored …
spectrum disorders (ASDs), but the functional impact of CNVs remains largely unexplored …