Human antibodies for viral infections
JE Crowe Jr - Annual review of immunology, 2022 - annualreviews.org
Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …
but the full potential to use passive immunization for infectious diseases has yet to be …
Breathing and tilting: mesoscale simulations illuminate influenza glycoprotein vulnerabilities
Influenza virus has resurfaced recently from inactivity during the early stages of the COVID-
19 pandemic, raising serious concerns about the nature and magnitude of future epidemics …
19 pandemic, raising serious concerns about the nature and magnitude of future epidemics …
[HTML][HTML] Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals
Unrelated individuals can produce genetically similar clones of antibodies, known as public
clonotypes, which have been seen in responses to different infectious diseases, as well as …
clonotypes, which have been seen in responses to different infectious diseases, as well as …
In vivo electroporation of plasmid DNA: a promising strategy for rapid, inexpensive, and flexible delivery of anti-viral monoclonal antibodies
S Pagant, RA Liberatore - Pharmaceutics, 2021 - mdpi.com
Since the first approval of monoclonal antibodies by the United States Food and Drug
Administration (FDA) in 1986, therapeutic antibodies have become one of the predominant …
Administration (FDA) in 1986, therapeutic antibodies have become one of the predominant …
An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer
N Suryadevara, AR Shiakolas… - The Journal of …, 2022 - Am Soc Clin Investig
The protective human antibody response to severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) focuses on the spike (S) protein, which decorates the virion surface and …
2 (SARS-CoV-2) focuses on the spike (S) protein, which decorates the virion surface and …
Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions
FJ Milder, M Jongeneelen, T Ritschel… - Proceedings of the …, 2022 - National Acad Sciences
For an efficacious vaccine immunogen, influenza hemagglutinin (HA) needs to maintain a
stable quaternary structure, which is contrary to the inherently dynamic and metastable …
stable quaternary structure, which is contrary to the inherently dynamic and metastable …
Antibody sequence determinants of viral antigen specificity
Throughout life, humans experience repeated exposure to viral antigens through infection
and vaccination, resulting in the generation of diverse, antigen-specific antibody repertoires …
and vaccination, resulting in the generation of diverse, antigen-specific antibody repertoires …
Antigen spacing on protein nanoparticles influences antibody responses to vaccination
D Ellis, A Dosey, S Boyoglu-Barnum, YJ Park… - Cell reports, 2023 - cell.com
Immunogen design approaches aim to control the specificity and quality of antibody
responses elicited by next-generation vaccines. Here, we use computational protein design …
responses elicited by next-generation vaccines. Here, we use computational protein design …
Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes
Understanding the human antibody response to emerging viral pathogens is key to
epidemic preparedness. As the size of the B cell response to a pathogenic-virus-protective …
epidemic preparedness. As the size of the B cell response to a pathogenic-virus-protective …
Convergent sequence features of antiviral B cells
Throughout life, humans experience repeated exposure to viral antigens through infection
and vaccination, building diverse antigen-specific antibody repertoires. In recent years …
and vaccination, building diverse antigen-specific antibody repertoires. In recent years …