Uric acid and cardiovascular disease: an update from molecular mechanism to clinical perspective

W Yu, JD Cheng - Frontiers in pharmacology, 2020 - frontiersin.org
Uric acid (UA) is the end product of purine nucleotide metabolism in the human body.
Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and …

Effects of uric acid on diabetes mellitus and its chronic complications

Q **ong, J Liu, Y Xu - International journal of endocrinology, 2019 - Wiley Online Library
With the deepening of the researches on uric acid, especially in the study of metabolic
diseases, uric acid has been found to be closely related to obesity, metabolic syndrome …

[HTML][HTML] Xanthine oxidoreductase: A leading actor in cardiovascular disease drama

L Polito, M Bortolotti, MG Battelli, A Bolognesi - Redox biology, 2021 - Elsevier
Cardiovascular diseases (CVD) are the leading cause of global mortality and their
pathogenesis lies mainly in the atherosclerotic process. There are close connections linking …

Early onset of hyperuricemia is associated with increased cardiovascular disease and mortality risk

L Li, M Zhao, C Wang, S Zhang, C Yun, S Chen… - Clinical Research in …, 2021 - Springer
Background Hyperuricemia is associated with cardiovascular mortality, but the association
of the age at hyperuricemia onset with cardiovascular disease (CVD) and mortality is still …

Emerging Roles of Xanthine Oxidoreductase in Chronic Kidney Disease

HW Korsmo, US Ekperikpe, IS Daehn - Antioxidants, 2024 - mdpi.com
Xanthine Oxidoreductase (XOR) is a ubiquitous, essential enzyme responsible for the
terminal steps of purine catabolism, ultimately producing uric acid that is eliminated by the …

[PDF][PDF] Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in …

A Klisic, N Kavaric, V Stanisic, S Vujcic… - Archives of Medical …, 2020 - termedia.pl
Results Endocan was significantly higher in the T2D group than in the controls. As endocan
concentration rose by 1 unit, the probability for higher HbA 1c concentration increased by …

Effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment

O Alfarisi, V Mave, S Gaikwad… - Antimicrobial agents …, 2018 - journals.asm.org
Diabetes mellitus (DM) and tuberculosis (TB) are two common diseases with increasing
geographic overlap and clinical interactions. The effect of DM and hemoglobin A1c (HbA1c) …

Serum uric acid levels and health outcomes in CKD: a prospective cohort study

S Wu, W Xue, H Yu, H Yu, Z Shi… - Nephrology Dialysis …, 2024 - academic.oup.com
Background Hyperuricemia is prevalent in individuals with chronic kidney disease (CKD).
Elevated serum uric acid (SUA) concentrations have been considered an independent risk …

Ethnic disparities in bidirectional causal effects between serum uric acid concentrations and kidney function: Trans-ethnic Mendelian randomization study

S Wu, M Kong, Y Song, A Peng - Heliyon, 2023 - cell.com
Introduction Researchers have investigated the causal effect between serum uric acid (SUA)
concentrations and kidney function for decades, but studies produced inconsistent results …

The serum uric acid to serum creatinine ratio is an independent risk factor for diabetic kidney disease

L Chen, Z Zhu, S Ye, M Zheng - Diabetes, metabolic syndrome and …, 2022 - Taylor & Francis
Purpose A retrospective study was designed to evaluate whether the serum uric acid to
serum creatinine ratio (SUA/SCr) can be used as an indicator of diabetic kidney disease …