Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology

C Wu, G Lorenzo, DA Hormuth, EABF Lima… - Biophysics …, 2022 - pubs.aip.org
Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …

Hemodynamic modeling, medical imaging, and machine learning and their applications to cardiovascular interventions

M Kadem, L Garber, M Abdelkhalek… - IEEE Reviews in …, 2022 - ieeexplore.ieee.org
Cardiovascular disease is a deadly global health crisis that carries a substantial financial
burden. Innovative treatment and management of cardiovascular disease straddles …

[HTML][HTML] Patient-specific modeling of blood flow in the coronary arteries

CA Taylor, K Petersen, N **ao, M Sinclair, Y Bai… - Computer Methods in …, 2023 - Elsevier
Patient-specific models of blood flow in the coronary arteries have entered clinical practice
worldwide to aid in the diagnosis and management of heart disease. This technology …

Analysis of finite element and finite volume methods for fluid-structure interaction simulation of blood flow in a real stenosed artery

D Lopes, R Agujetas, H Puga, J Teixeira, R Lima… - International Journal of …, 2021 - Elsevier
This paper presents a qualitative and quantitative comparison between the finite element
and the finite volume methods for the fluid-structure interaction simulation of blood flow …

Clinical impact of computational heart valve models

M Toma, S Singh-Gryzbon, E Frankini, Z Wei… - Materials, 2022 - mdpi.com
This paper provides a review of engineering applications and computational methods used
to analyze the dynamics of heart valve closures in healthy and diseased states …

Attention-based multi-fidelity machine learning model for fractional flow reserve assessment

H Yang, BK Nallamothu, CA Figueroa… - Computer Methods in …, 2024 - Elsevier
Abstract Coronary Artery Disease (CAD) is one of the most common forms of heart disease,
caused by a buildup of atherosclerotic plaque in the coronary arteries. When this buildup is …

Effects of non-Newtonian viscosity on arterial and venous flow and transport

S Lynch, N Nama, CA Figueroa - Scientific Reports, 2022 - nature.com
It is well known that blood exhibits non-Newtonian viscosity, but it is generally modeled as a
Newtonian fluid. However, in situations of low shear rate, the validity of the Newtonian …

Patient‐specific computational modeling of endovascular aneurysm repair: State of the art and future directions

S Avril, MW Gee, A Hemmler… - International journal for …, 2021 - Wiley Online Library
Endovascular aortic repair (EVAR) has become the preferred intervention option for aortic
aneurysms and dissections. This is because EVAR is much less invasive than the alternative …

Comparative study of human and murine aortic biomechanics and hemodynamics in vascular aging

SE Hopper, F Cuomo, J Ferruzzi, NS Burris… - Frontiers in …, 2021 - frontiersin.org
Introduction: Aging has many effects on the cardiovascular system, including changes in
structure (aortic composition, and thus stiffening) and function (increased proximal blood …

Impact of TAVR on coronary artery hemodynamics using clinical measurements and image‐based patient‐specific in silico modeling

L Garber, S Khodaei, N Maftoon… - Scientific Reports, 2023 - nature.com
In recent years, transcatheter aortic valve replacement (TAVR) has become the leading
method for treating aortic stenosis. While the procedure has improved dramatically in the …