The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens

A Ulfig, LI Leichert - Cellular and Molecular Life Sciences, 2021 - Springer
Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …

The ArcAB two-component system: function in metabolism, redox control, and infection

AN Brown, MT Anderson, MA Bachman… - Microbiology and …, 2022 - Am Soc Microbiol
ArcAB, also known as the Arc system, is a member of the two-component system family of
bacterial transcriptional regulators and is composed of sensor kinase ArcB and response …

Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung

JD Gawronski, SMS Wong… - Proceedings of the …, 2009 - National Acad Sciences
Rapid genome-wide identification of genes required for infection would expedite studies of
bacterial pathogens. We developed genome-scale “negative selection” technology that …

Environmental adaptation and diversification of bacterial two-component systems

AF Alvarez, D Georgellis - Current Opinion in Microbiology, 2023 - Elsevier
Bacterial two-component systems (TCS) are versatile signaling mechanisms that govern
cellular responses to diverse environmental cues. These systems rely on phosphoryl-group …

Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress

CL Holmes, AE Wilcox, V Forsyth, SN Smith… - PLoS …, 2023 - journals.plos.org
Gram-negative bacteremia is a major cause of global morbidity involving three phases of
pathogenesis: initial site infection, dissemination, and survival in the blood and filtering …

ArcS, the Cognate Sensor Kinase in an Atypical Arc System of Shewanella oneidensis MR-1

J Lassak, AL Henche, L Binnenkade… - Applied and …, 2010 - Am Soc Microbiol
The availability of oxygen is a major environmental factor for many microbes, in particular for
bacteria such as Shewanella species, which thrive in redox-stratified environments. One of …

Towards development of electrogenetics using electrochemically active bacteria

A Hirose, A Kouzuma, K Watanabe - Biotechnology advances, 2019 - Elsevier
Owing to the ability for efficient electric interaction with electrodes, electrochemically active
bacteria (EAB) attract considerable attention in biotechnology. These bacteria are involved …

Mechanisms underlying interactions between two abundant oral commensal bacteria

D Perera, A McLean, V Morillo-López… - The ISME …, 2022 - academic.oup.com
Complex polymicrobial biofilm communities are abundant in nature particularly in the human
oral cavity where their composition and fitness can affect health. While the study of these …

Microbial oxidative stress response: novel insights from environmental facultative anaerobic bacteria

H Fu, J Yuan, H Gao - Archives of biochemistry and biophysics, 2015 - Elsevier
Facultative bacteria can grow under either oxic or anoxic conditions. While oxygen provides
substantial advantages in energy yield by respiration, it can become life-threatening …

The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium

C Pardo-Esté, AA Hidalgo, C Aguirre, AC Briones… - PLoS …, 2018 - journals.plos.org
Salmonella enterica Serovar Typhimurium (S. Typhimurium) is an intracellular bacterium
that overcomes host immune system barriers for successful infection. The bacterium …