Pneumonia-induced inflammation, resolution and cardiovascular disease: causes, consequences and clinical opportunities

C Stotts, VF Corrales-Medina, KJ Rayner - Circulation research, 2023 - ahajournals.org
Pneumonia is inflammation in the lungs, which is usually caused by an infection. The
symptoms of pneumonia can vary from mild to life-threatening, where severe illness is often …

A lipid perspective on regulated pyroptosis

Y Qiu, YN Shi, N Zhu, S Zhang… - International …, 2023 - pmc.ncbi.nlm.nih.gov
Pyroptosis is a novel pro-inflammatory cell programmed death dependent on Gasdermin
(GSMD) family-mediated membrane pore formation and subsequent cell lysis, accompanied …

SARS-CoV-2 infects adipose tissue in a fat depot-and viral lineage-dependent manner

TD Saccon, F Mousovich-Neto, RG Ludwig… - Nature …, 2022 - nature.com
Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue
infection and disease progression has been proposed. Here we demonstrate that SARS …

GP consultation rates for sequelae after acute covid-19 in patients managed in the community or hospital in the UK: population based study

HR Whittaker, C Gulea, A Koteci, C Kallis, AD Morgan… - bmj, 2021 - bmj.com
Objectives To describe the rates for consulting a general practitioner (GP) for sequelae after
acute covid-19 in patients admitted to hospital with covid-19 and those managed in the …

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants

SE Farley, JE Kyle, HC Leier, LM Bramer… - Nature …, 2022 - nature.com
A comprehensive understanding of host dependency factors for SARS-CoV-2 remains
elusive. Here, we map alterations in host lipids following SARS-CoV-2 infection using …

The effect of polyunsaturated fatty acids on the severity and mortality of COVID patients: A systematic review

A Mazidimoradi, E Alemzadeh, E Alemzadeh… - Life sciences, 2022 - Elsevier
Background Covid-19 mortality is largely associated with a severe increase in inflammatory
cytokines and polyunsaturated fatty acids (PUFAs) play an important role in modulating …

Redox homeostasis alteration is restored through melatonin treatment in COVID-19 patients: A preliminary study

ME Soto, I Pérez-Torres, L Manzano-Pech… - International Journal of …, 2024 - mdpi.com
Type II pneumocytes are the target of the SARS-CoV-2 virus, which alters their redox
homeostasis to increase reactive oxygen species (ROS). Melatonin (MT) has antioxidant …

[HTML][HTML] Hyperglycemia and loss of redox homeostasis in COVID-19 patients

ME Soto, V Guarner-Lans, E Díaz-Díaz… - Cells, 2022 - mdpi.com
The infection with SARS-CoV-2 impairs the glucose–insulin axis and this contributes to
oxidative (OS) and nitrosative (NSS) stress. Here, we evaluated changes in glucose …

Fatty acid metabolism in T-cell function and differentiation

Y Endo, T Kanno, T Nakajima - International Immunology, 2022 - academic.oup.com
Immunometabolism has recently emerged as a field of study examining the intersection
between immunology and metabolism. Studies in this area have yielded new findings on the …

Circulating polyunsaturated fatty acids and COVID-19: a prospective cohort study and Mendelian randomization analysis

Y Sun, R Chatterjee, A Ronanki, K Ye - Frontiers in Medicine, 2022 - frontiersin.org
Higher circulating polyunsaturated fatty acids (PUFAs), especially omega-3 fatty acids, have
been linked to a better prognosis in patients of coronavirus disease 2019 (COVID-19) …