Despite the damaging effect on tissues at a high concentration, it has been gradually
established that oxidative stress plays a positive role during angiogenesis. In adults …

Simple Summary In this review paper, we explore the role of chronic inflammation in the
pathogenesis of prostatic diseases, such as chronic prostatitis, benign prostatic hyperplasia …

Hypoxia is a known feature of solid tumors and a critical promoter of tumor hallmarks.
Hypoxia influences tumor immunity in a way favoring immune evasion and resistance …

Toll-like receptors (TLRs) are a class of pattern recognition receptors that play a bridging
role in innate immunity and adaptive immunity. The activated TLRs not only induce …

Recent evidence suggests that processes of inflammation and angiogenesis are
interconnected, especially in human pathologies. Newly formed blood vessels enable the …

Angiogenesis refers to new capillaries that sprout and remold from existing vessels. The
mechanism of angiogenesis is very complex. Many factors promote angiogenesis in the …

ABSTRACT TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune
cells where it senses pathogen-associated molecular patterns and initiates innate immune …

Simple Summary The tumoral microenvironment comprises cancer cells and surrounding
components, including immune and endothelial cells, along with the extracellular matrix. As …

Obesity is a weight-related disorder characterized by excessive adipose tissue growth and
dysfunction which leads to the onset of a systemic chronic low-grade inflammatory state …

Endothelial cells (EC) are able to actively control vascular permeability, coagulation, blood
pressure and angiogenesis. Most recently, a role for endothelial cells in the immune …