Ultrasound-assisted green synthesis of triazole-based azomethine/thiazolidin-4-one hybrid inhibitors for cancer therapy through targeting dysregulation signatures of …
AH Abdelmonsef, AM El-Saghier… - Green Chemistry Letters …, 2023 - Taylor & Francis
The overexpression of Rab proteins was linked to cancer development, making this family of
proteins an attractive drug target for the identification of novel inhibitors against tumor …
proteins an attractive drug target for the identification of novel inhibitors against tumor …
Thiazole-based thiosemicarbazones: Synthesis, cytotoxicity evaluation and molecular docking study
SM Gomha, HA Abdelhady, DZH Hassain… - Drug design …, 2021 - Taylor & Francis
Introduction Hybrid drug design has developed as a prime method for the development of
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …
New amino acid Schiff bases as anticancer agents via potential mitochondrial complex I-associated hexokinase inhibition and targeting AMP-protein kinases/mTOR …
Two series of novel amino acid Schiff base ligands containing heterocyclic moieties, such as
quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by …
quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by …
Design, synthetic approach, in silico molecular docking and antibacterial activity of quinazolin-2, 4-dione hybrids bearing bioactive scaffolds
Antimicrobial resistance (AMR) is one of ten global public health threats facing humanity.
This created the need to identify and develop effective inhibitors as antimicrobial agents. In …
This created the need to identify and develop effective inhibitors as antimicrobial agents. In …
Synthesis, anticancer evaluation, computer-aided docking studies, and ADMET prediction of 1, 2, 3-triazolyl-pyridine hybrids as human aurora B kinase inhibitors
A novel series of 1, 2, 3-triazolyl-pyridine hybrids were prepared through the reaction of the
triazole derivative (1) with the appropriate aldehyde (2a–g) and malononitrile or ethyl …
triazole derivative (1) with the appropriate aldehyde (2a–g) and malononitrile or ethyl …
Synthesis, in silico and in vitro assessment of new quinazolinones as anticancer agents via potential AKT inhibition
A series of novel quinazolinone derivatives (2–13) was synthesized and examined for their
cytotoxicity to HepG2, MCF-7, and Caco-2 in an MTT assay. Among these derivatives …
cytotoxicity to HepG2, MCF-7, and Caco-2 in an MTT assay. Among these derivatives …
Novel Quinazolin-2,4-Dione Hybrid Molecules as Possible Inhibitors Against Malaria: Synthesis and in silico Molecular Docking Studies
A Haredi Abdelmonsef, M Eldeeb Mohamed… - Frontiers in Molecular …, 2020 - frontiersin.org
The research explores the synthesis of a series of novel hybrid quinazolin-2, 4-dione
analogs bearing acetyl/amide bridged-nitrogen heterocyclic moieties such as azetidinone …
analogs bearing acetyl/amide bridged-nitrogen heterocyclic moieties such as azetidinone …
Synthesis, identification, computer-aided docking studies, and ADMET prediction of novel benzimidazo-1, 2, 3-triazole based molecules as potential antimicrobial …
2-azido-1 H-benzo [d] imidazole derivatives 1a, b were reacted with a β-ketoester such as
acetylacetone in the presence of sodium ethoxide to obtain the desired molecules 2a, b. The …
acetylacetone in the presence of sodium ethoxide to obtain the desired molecules 2a, b. The …
Synthesis, molecular docking studies and in silico admet screening of new heterocycles linked thiazole conjugates as potent anti-hepatic cancer agents
Thiazoles are important scaffolds in organic chemistry. Biosynthesis of thiazoles is
considered to be an excellent target for the design of novel classes of therapeutic agents. In …
considered to be an excellent target for the design of novel classes of therapeutic agents. In …
Eco-Friendly Synthesis, Biological Evaluation, and In Silico Molecular Docking Approach of Some New Quinoline Derivatives as Potential Antioxidant and …
AM El-Saghier, M El-Naggar, AHM Hussein… - Frontiers in …, 2021 - frontiersin.org
A new series of quinoline derivatives 5–12 were efficiently synthesized via one-pot
multicomponent reaction (MCR) of resorcinol, aromatic aldehydes, β-ketoesters, and …
multicomponent reaction (MCR) of resorcinol, aromatic aldehydes, β-ketoesters, and …