Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2024 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts

MM Hammouda, MM Rashed, KM Elattar… - RSC advances, 2023 - pubs.rsc.org
Nano-catalysts are of special character for the synthesis of organic molecules with high
efficiency, and exceptional physicochemical properties. The objective of this study was to …

Orthosteric and allosteric modulation of human HCAR2 signaling complex

C Mao, M Gao, SK Zang, Y Zhu, DD Shen… - Nature …, 2023 - nature.com
Hydroxycarboxylic acids are crucial metabolic intermediates involved in various
physiological and pathological processes, some of which are recognized by specific …

Visible-Light-Mediated, Organophotocatalytic C–H Thiocyanation of Pyrazolo[1,5-a]pyrimidines

P Pattanayak, ANV Satyanarayana… - The Journal of Organic …, 2024 - ACS Publications
Herein, we report a metal-free, organophotoredox-catalyzed sustainable C–H thiocyanation
of a biologically active class of N-heterocycles, pyrazolo [1, 5-a] pyrimidines, with potassium …

Multicomponent Synthesis of 5‐Cyano‐pyrazolo[1,5‐a]pyrimidines Enabled by Aerobic Manganese Catalysis

HT Qu, ZH Wu, GC Zhong, YC Zhang… - Advanced Synthesis …, 2023 - Wiley Online Library
An aerobic Mn (III)-catalyzed one-pot three-component synthesis of 5-cyano-pyrazolo [1, 5-
a] pyrimidines has been described. The synergistic combination of Strecker reaction and …

Construction of pyrazolo [1, 5-a] pyrimidines and pyrimido [1, 2-b] indazoles with calcium carbide as an alkyne source

X You, B Wang, F Wen, Z Li - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
An efficient method for the construction of 5-arylpyrazolo [1, 5-a] pyrimidines using calcium
carbide as a solid alkyne source instead of flammable and explosive gaseous acetylene …

PIDA as an Iodinating Reagent: Visible‐Light‐Induced Iodination of Pyrazolo[1,5‐a]pyrimidines and Other Heteroarenes

S Paul, S Das, T Choudhuri, P Sikdar… - Chemistry–An Asian …, 2024 - Wiley Online Library
We have developed a visible‐light‐mediated convenient and efficient strategy for the
iodination of heteroarenes using diacetoxyiodobenzene (PIDA) under photocatalyst‐free …

Inverse Electron Demand Diels–Alder-Type Heterocycle Syntheses with 1, 2, 3-Triazine 1-Oxides: Expanded Versatility

S Biswas, L De Angelis, G Rivera, H Arman… - Organic …, 2023 - ACS Publications
1, 2, 3-Triazine 1-oxides are remarkably effective substrates for inverse electron demand
Diels–Alder reactions. Formed from vinyldiazoacetates via reaction with tert-butyl nitrite …

Synthesis, antimicrobial and antioxidant activities of some new pyrazolo[1,5-a]pyrimidine and imidazo[1,2-b]pyrazole derivatives based isoxazole

ZM Alamshany, NY Tashkandi… - Synthetic …, 2023 - Taylor & Francis
A new set of pyrazolo [1, 5-a] pyrimidines 5–8 and imidazo [1, 2-b] pyrazoles 9–11
incorporating isoxazole as pharmacologically attractive cores were synthesized starting with …

Developments of pyridodipyrimidine heterocycles and their biological activities

MM Hammouda, KM Elattar, AY El-Khateeb… - Molecular Diversity, 2024 - Springer
The entitled review aimed to assemble and highlight the synthetic approaches and
biological aspects of heterocycles with pyridodipyrimidine motifs. The recent synthetic …