Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

Airspaces of the lung are lined by an epithelium whose cellular composition changes along
the proximal-to-distal axis to meet local functional needs for mucociliary clearance …

We report that two oncogenes coamplified on chromosome 3q26, PRKCI and SOX2,
cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein …

Background The human airway epithelium consists of 4 major cell types: ciliated, secretory,
columnar and basal cells. During natural turnover and in response to injury, the airway basal …

Regenerative therapy using stem cells is a promising approach for the treatment of stroke.
Recently, we reported that dental pulp stem cells (DPSC) ameliorated ischemic tissue injury …

The cancer stem-cell (CSC) hypothesis suggests that there is a small subset of cancer cells
that are responsible for tumor initiation and growth, possessing properties such as indefinite …

Despite advances in surgery, chemotherapy, and radiotherapy over the last decades, the
death rate from lung cancer has remained largely unchanged, which is mainly due to …

Lung cancer is the second most common malignancy and the leading cause of cancer-
related death in the western world. Moreover, despite advances in surgery, chemotherapy …

The airway epithelium is in direct contact with the environment and therefore constantly at
risk for injury. Basal cells (BCs) have been found to repair the surface epithelium (SE), but …

Background The small airway epithelium (SAE), the cell population that covers the human
airway surface from the 6 th generation of airway branching to the alveoli, is the major site of …