Decoding hepatocarcinogenesis from a noncoding RNAs perspective

MKA El‐Aziz, A Dawoud, CJ Kiriacos… - Journal of cellular …, 2023 - Wiley Online Library
Being a leading lethal malignancy worldwide, the pathophysiology of hepatocellular
carcinoma (HCC) has gained a lot of interest. Yet, underlying mechanistic basis of the liver …

[HTML][HTML] lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment

H **, W Du, W Huang, J Yan, Q Tang, Y Chen… - … Therapy-Nucleic Acids, 2021 - cell.com
Breast cancer is a malignant tumor that has a high mortality rate and mostly occurs in
women. Although significant progress has been made in the implementation of personalized …

Recent advances in tannic acid (gallotannin) anticancer activities and drug delivery systems for efficacy improvement; a comprehensive review

R A. Youness, R Kamel, N A. Elkasabgy, P Shao… - Molecules, 2021 - mdpi.com
Tannic acid is a chief gallo-tannin belonging to the hydrolysable tannins extracted from gall
nuts and other plant sources. A myriad of pharmaceutical and biological applications in the …

[HTML][HTML] MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer

RY Mekky, MF Ragab, T Manie, AA Attia… - Translational …, 2023 - Elsevier
Background Triple negative breast cancer (TNBC) is known as hot immunogenic tumor. Yet,
it is one of the most aggressive BC subtypes. TNBC evolve several tactics to evade the …

Roles of miRNA and IncRNA in triple-negative breast cancer

J Xu, K Wu, Q Jia, X Ding - Journal of Zhejiang University-science b, 2020 - Springer
Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast
cancer without effective targeted therapies, which makes its pathogenesis an important …

Emerging role of circular RNAs in hepatocellular carcinoma immunotherapy

T Abaza, MKA El-Aziz, KA Daniel, P Karousi… - International Journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is a highly fatal malignancy with limited therapeutic options
and high recurrence rates. Recently, immunotherapeutic agents such as immune checkpoint …

lncRNA PVT1 promotes tumorigenesis of colorectal cancer by stabilizing miR-16-5p and interacting with the VEGFA/VEGFR1/AKT axis

H Wu, M Wei, X Jiang, J Tan, W Xu, X Fan… - … Therapy-Nucleic Acids, 2020 - cell.com
Recently, the long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1)
was reported to be involved in the pathogenesis of several cancers, including human …

Let-7a/cMyc/CCAT1/miR-17–5p Circuit Re-sensitizes Atezolizumab Resistance in Triple Negative Breast Cancer through Modulating PD-L1

NA Selem, H Nafae, T Manie, RA Youness… - Pathology-Research and …, 2023 - Elsevier
Background Triple negative breast cancer (TNBC) is an immunogenically hot tumor. The
immune checkpoint blockades (ICBs) have been recently emerged as promising therapeutic …

Phytochemical-derived tumor-associated macrophage remodeling strategy using Phoenix dactylifera L. boosted photodynamic therapy in melanoma via H19/iNOS/PD …

AH Soliman, RA Youness, AA Sebak… - Photodiagnosis and …, 2023 - Elsevier
Background The tumor microenvironment (TME) represents a barrier to PDT efficacy among
melanoma patients. The aim of this study is to employ a novel muti-tactic TME-remodeling …

MALAT-1/p53/miR-155/miR-146a ceRNA circuit tuned by methoxylated quercitin glycoside alters immunogenic and oncogenic profiles of breast cancer

M Abdel-Latif, A Riad, RA Soliman, AM Elkhouly… - Molecular and Cellular …, 2022 - Springer
Abstract Triple-Negative Breast Cancer (TNBC) is one of the most aggressive and hot BC
subtypes. Our research group has recently shed the light on the utility of natural compounds …