Efficient recombinase-mediated cassette exchange in hPSCs to study the hepatocyte lineage reveals AAVS1 locus-mediated transgene inhibition
Tools for rapid and efficient transgenesis in" safe harbor" loci in an isogenic context remain
important to exploit the possibilities of human pluripotent stem cells (hPSCs). We created …
important to exploit the possibilities of human pluripotent stem cells (hPSCs). We created …
Sustained expression from DNA vectors
SP Wong, O Argyros, RP Harbottle - Advances in genetics, 2015 - Elsevier
DNA vectors have the potential to become powerful medical tools for treatment of human
disease. The human body has, however, developed a range of defensive strategies to detect …
disease. The human body has, however, developed a range of defensive strategies to detect …
MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells
Purpose: Advanced castration-resistant prostate cancer, for which there are few treatment
options, remains one of the leading causes of cancer death. MicroRNAs (miRNA) have …
options, remains one of the leading causes of cancer death. MicroRNAs (miRNA) have …
HSV as a vector in vaccine development and gene therapy
P Marconi, R Argnani, AL Epstein… - Pharmaceutical …, 2009 - Springer
The verydeepknowledge acquiredon the genetics and molecularbiologyof herpessimplex
virus (HSV), major human pathogenwhoselifestyle is basedon a long-termdual interaction …
virus (HSV), major human pathogenwhoselifestyle is basedon a long-termdual interaction …
Optimised coding sequence and promoter
An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter
may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood …
may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood …
Advances in liver-directed gene therapy for hepatocellular carcinoma by non-viral delivery systems
B Ding, T Li, J Zhang, L Zhao, G Zhai - Current gene therapy, 2012 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is a malignancy with a high mortality. Gene therapy
provides a promising way for the treatment of HCC. Efficient gene delivery system, suitable …
provides a promising way for the treatment of HCC. Efficient gene delivery system, suitable …
HSV as a vector in vaccine development and gene therapy
P Marconi, R Argnani, AL Epstein, R Manservigi - Human Vaccines, 2008 - Taylor & Francis
The very deep knowledge acquired on the genetics and molecular biology of herpes
simplex virus (HSV), major human pathogen whose lifestyle is based on a long-term dual …
simplex virus (HSV), major human pathogen whose lifestyle is based on a long-term dual …
Progress and prospects: biological properties and technological advances of herpes simplex virus type 1-based amplicon vectors
AL Epstein - Gene therapy, 2009 - nature.com
The last two years have seen significant advances in our understanding of the cellular
innate responses elicited or activated by the entry of amplicon particles, which may, in part …
innate responses elicited or activated by the entry of amplicon particles, which may, in part …
Novel tumour‐specific promoters for transcriptional targeting of hepatocellular carcinoma by herpes simplex virus vectors
Background Hepatocellular carcinoma (HCC) is a cancer of poor prognosis, with limited
success in patient treatment, which it makes an excellent target for gene therapy and viral …
success in patient treatment, which it makes an excellent target for gene therapy and viral …
Human hepatocellular carcinoma: expression profiles-based molecular interpretations and clinical applications
KM Hui - Cancer letters, 2009 - Elsevier
Primary liver cancer is the fifth most common cancer worldwide and hepatocellular
carcinoma (HCC) accounts for over 85% of all primary liver cancers. The clinical …
carcinoma (HCC) accounts for over 85% of all primary liver cancers. The clinical …