Application of combinatorial optimization strategies in synthetic biology

G Naseri, MAG Koffas - Nature communications, 2020 - nature.com
In the first wave of synthetic biology, genetic elements, combined into simple circuits, are
used to control individual cellular functions. In the second wave of synthetic biology, the …

β-Ionone: Its occurrence and biological function and metabolic engineering

A Paparella, L Shaltiel-Harpaza, M Ibdah - Plants, 2021 - mdpi.com
β-Ionone is a natural plant volatile compound, and it is the 9, 10 and 9′, 10′ cleavage
product of β-carotene by the carotenoid cleavage dioxygenase. β-Ionone is widely …

[HTML][HTML] Modular engineering for microbial production of carotenoids

C Li, CA Swofford, AJ Sinskey - Metabolic Engineering Communications, 2020 - Elsevier
There is an increasing demand for carotenoids due to their applications in the food, flavor,
pharmaceutical and feed industries, however, the extraction and synthesis of these …

Compartmentalization and transporter engineering strategies for terpenoid synthesis

K **, H **a, Y Liu, J Li, G Du, X Lv, L Liu - Microbial Cell Factories, 2022 - Springer
Microbial cell factories for terpenoid synthesis form a less expensive and more environment-
friendly approach than chemical synthesis and extraction, and are thus being regarded as …

Utilization of glycosyltransferases as a seamless tool for synthesis and modification of the oligosaccharides-A review

MY Ali, F Liaqat, MI Khazi, S Sethupathy… - International Journal of …, 2023 - Elsevier
Glycosyltransferases (GTs) catalyze the transfer of active monosaccharide donors to
carbohydrates to create a wide range of oligosaccharide structures. GTs display strong …

Establishment of strigolactone-producing bacterium-yeast consortium

S Wu, X Ma, A Zhou, A Valenzuela, K Zhou, Y Li - Science Advances, 2021 - science.org
Strigolactones (SLs) are a class of phytohormones playing diverse roles in plant growth and
development, yet the limited access to SLs is largely impeding SL-based foundational …

Regulation of carotenoid degradation and production of apocarotenoids in natural and engineered organisms

MH Liang, YJ He, DM Liu, JG Jiang - Critical Reviews in …, 2021 - Taylor & Francis
Carotenoids are important precursors of a wide range of apocarotenoids with their functions
including: hormones, pigments, retinoids, volatiles, and signals, which can be used in the …

A modular pathway engineering strategy for the high-level production of β-ionone in Yarrowia lipolytica

Y Lu, Q Yang, Z Lin, X Yang - Microbial cell factories, 2020 - Springer
Background The GRAS and oleaginous yeast Yarrowia lipolytica (Y. lipolytica) is an
attractive cell factory for the production of chemicals and biofuels. The production of many …

Carotenoids in drug discovery and medicine: pathways and molecular targets implicated in human diseases

DS Metibemu, IV Ogungbe - Molecules, 2022 - mdpi.com
Carotenoids are isoprenoid-derived natural products produced in plants, algae, fungi, and
photosynthetic bacteria. Most animals cannot synthesize carotenoids because the …

Advances in the metabolic engineering of Saccharomyces cerevisiae and Yarrowia lipolytica for the production of β-carotene

Q Guo, QQ Peng, YW Li, F Yan, YT Wang… - Critical Reviews in …, 2024 - Taylor & Francis
Abstract β-Carotene is one kind of the most important carotenoids. The major functions of β-
carotene include the antioxidant and anti-cardiovascular properties, which make it a growing …