Hypodontia, or tooth agenesis, is the most prevalent craniofacial malformation in humans. It
may occur as part of a recognised genetic syndrome or as a nonsyndromic isolated trait …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

Orofacial clefting is considered one of the commonest birth defects worldwide. It presents as
cleft lip only, isolated cleft palate or cleft lip and palate. The condition has a diverse genetic …

Objective: The objective of this systematic review was (a) to explore the current clinical
applications of AI/ML (Artificial intelligence and Machine learning) techniques in diagnosis …

Non-syndromic cleft lip with palate (NSCLP) is the most serious sub-phenotype of non-
syndromic orofacial clefts (NSOFC), which are the most common craniofacial birth defects in …

Isolated cleft palate (CPO) is the rarest form of oral clefting. The incidence of CPO varies
substantially by geography from 1.3 to 25.3 per 10,000 live births, with the highest rates in …

Mammalian palatogenesis is a highly regulated morphogenetic process during which the
embryonic primary and secondary palatal shelves develop as outgrowths from the medial …

Patients with one or more developmentally absent teeth are routinely encountered in dental
practice. Tooth agenesis can be associated with significant functional, aesthetic and psycho …

The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …

There is considerable ambiguity in the use of terminology when referring to orofacial clefts
(OFCs). Many clinicians incorrectly refer to OFCs as deformities, which are said to be the …