Two-photon calcium imaging of neuronal activity
In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …
activity in the intact brain. It is based on the principle that, when neurons fire action …
Probing neural codes with two-photon holographic optogenetics
Optogenetics ushered in a revolution in how neuroscientists interrogate brain function.
Because of technical limitations, the majority of optogenetic studies have used low spatial …
Because of technical limitations, the majority of optogenetic studies have used low spatial …
[HTML][HTML] Fast and sensitive GCaMP calcium indicators for imaging neural populations
Calcium imaging with protein-based indicators, is widely used to follow neural activity in
intact nervous systems, but current protein sensors report neural activity at timescales much …
intact nervous systems, but current protein sensors report neural activity at timescales much …
High-performance calcium sensors for imaging activity in neuronal populations and microcompartments
Calcium imaging with genetically encoded calcium indicators (GECIs) is routinely used to
measure neural activity in intact nervous systems. GECIs are frequently used in one of two …
measure neural activity in intact nervous systems. GECIs are frequently used in one of two …
Spontaneous behaviors drive multidimensional, brainwide activity
INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …
Reprogramming tumour-associated macrophages to outcompete cancer cells
In metazoan organisms, cell competition acts as a quality control mechanism to eliminate
unfit cells in favour of their more robust neighbours,. This mechanism has the potential to be …
unfit cells in favour of their more robust neighbours,. This mechanism has the potential to be …
Suite2p: beyond 10,000 neurons with standard two-photon microscopy
The combination of two-photon microscopy recordings and powerful calcium-dependent
fluorescent sensors enables simultaneous recording of unprecedentedly large populations …
fluorescent sensors enables simultaneous recording of unprecedentedly large populations …
Map** of brain activity by automated volume analysis of immediate early genes
Understanding how neural information is processed in physiological and pathological states
would benefit from precise detection, localization, and quantification of the activity of all …
would benefit from precise detection, localization, and quantification of the activity of all …
Sensitive red protein calcium indicators for imaging neural activity
Genetically encoded calcium indicators (GECIs) allow measurement of activity in large
populations of neurons and in small neuronal compartments, over times of milliseconds to …
populations of neurons and in small neuronal compartments, over times of milliseconds to …
Genetic dissection of neural circuits: a decade of progress
Tremendous progress has been made since Neuron published our Primer on genetic
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …