AGE/RAGE signaling has been a well‐studied cascade in many different disease states,
particularly diabetes. Due to the complex nature of the receptor and multiple intersecting …

Oxidative stress plays a pivotal role in the development of diabetes complications, both
microvascular and cardiovascular. The metabolic abnormalities of diabetes cause …

Vlassara H, Palace MR (Department of Geriatrics, Division of Experimental Diabetes and
Ageing, Mount Sinai School of Medicine, and Department of Medicine, Division of …

Background: Idiopathic epiretinal membrane (iERM) is a fibrocellular membrane that
proliferates on the inner surface of the retina at the macular area. Membrane contraction is …

The formation of advanced glycation end products (AGEs) is a key pathophysiological event
with links to a range of important human diseases. It is now clear that AGEs may act as …

The pathogenesis of diabetic retinopathy is multifactorial, and a range of hyperglycemia-
linked pathways have been implicated in the initiation and progression of this condition. All …

Advanced glycation end products (AGEs) have been implicated in vision loss associated
with macula degeneration, cataract formation, diabetic retinopathy and glaucoma. This …

Macromolecules comprise only 2% of vitreous, yet are responsible for its gel state,
transparency, and physiologic function (s) within the eye. Myopia and aging alter collagen …

Vitreous endo-tamponades are commonly used in the treatment of retinal detachments and
tears. They function by providing a tamponading force to support the retina after retina …

PURPOSE: To report the use of optical coherence tomography (OCT) for evaluation of
diffuse diabetic macular edema (DME) before and after vitrectomy. DESIGN: Interventional …