Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

Medulloblastoma is the most common pediatric malignant brain tumor. Advances in
molecular profiling have uncovered significant heterogeneity among medulloblastomas and …

Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct
molecular subgroups. Whereas genomic characteristics of these subgroups are well …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

In 2012, an international consensus paper reported that medulloblastoma comprises four
molecular subgroups (WNT, SHH, Group 3, and Group 4), each associated with distinct …

Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation.
Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively …

DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

In the 5th edition of the WHO CNS tumor classification (CNS5, 2021), multiple molecular
characteristics became essential diagnostic criteria for many additional CNS tumor types …

Background Atypical teratoid/rhabdoid tumors (ATRTs) are known to exhibit molecular and
clinical heterogeneity even though SMARCB1 inactivation is the sole recurrent genetic event …