The ubiquitin–proteasome system (UPS) is a multi-step process that serves as the primary
pathway for protein degradation within cells. UPS activity also plays a crucial role in …

Lung cancer stands as the leading cause of mortality among all types of tumors, with over
40% of cases being lung adenocarcinoma (LUAD). Family with sequence similarity 83 …

S-phase kinase-associated protein 2 (Skp2) is an F-box protein overexpressed in human
cancers and linked with poor prognosis. It triggers cancer pathogenesis, including stemness …

Natural products as starting templates have shown historically major contribution to
development of drugs. Inspired by the structure–function of an anticancer natural alkaloid …

Azoospermia and severe oligozoospermia represent the most extreme forms of male
infertility. Despite their prevalence, the genetic foundations of these conditions are not well …

Backgrounds. Glioma stands as one of the most formidable brain tumor types, with patient
outcomes remaining bleak even in the face of advancements in treatment modalities …

Abstract RNF6 (RING finger protein 6), an atypical RING-type ubiquitin ligase, has been
reported to be a potential tumor promoter in several human cancers. However, the role of …

Abstract Background Prostate cancer (PCa) is the second‐leading cause of cancer
mortalities in the United States and is the most commonly diagnosed malignancy in men …

The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has
resulted in unprecedented global health challenges, including millions of infections and …

Prostate cancer (PCa) is the second-leading cause of cancer mortalities in the US and is the
most commonly diagnosed malignancy in African American men. Despite androgen …