A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …

Introduction: The opioid epidemic has become an immense problem in North America, and
despite decades of research on the most effective means to treat opioid use disorder (OUD) …

Since antiquity, Cannabis has provoked enormous intrigue for its potential medicinal
properties as well as for its unique pharmacological effects. The elucidation of its major …

Cannabis has been widely used as a medicinal agent in Eastern medicine with earliest
evidence in ancient Chinese practice dating back to 2700 BC. Over time, the use of medical …

Medical cannabis (MC) is used for a variety of conditions including chronic pain. The goal of
this report was to provide an in-depth qualitative exploration of patient perspectives on the …

Pain perception can be powerfully influenced by an individual9s expectations and beliefs.
Although the cortical circuitry responsible for pain modulation has been thoroughly …

This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …

Although type 1 cannabinoid receptors (CB 1 Rs) are expressed abundantly throughout the
brain, the presence of type 2 cannabinoid receptors (CB 2 Rs) in neurons is still somewhat …

Over 50 million Americans endure chronic pain where many do not receive adequate
treatment and self-medicate to manage their pain by taking substances like opioids and …

The diversity of receptor signaling is increased by receptor heteromerization leading to
dynamic regulation of receptor function. While a number of studies have demonstrated that …