Recent advances in DNA origami-engineered nanomaterials and applications

P Zhan, A Peil, Q Jiang, D Wang, S Mousavi… - Chemical …, 2023 - ACS Publications
DNA nanotechnology is a unique field, where physics, chemistry, biology, mathematics,
engineering, and materials science can elegantly converge. Since the original proposal of …

DNA origami-based protein networks: from basic construction to emerging applications

G Kong, M **ong, L Liu, L Hu, HM Meng, G Ke… - Chemical Society …, 2021 - pubs.rsc.org
Natural living systems are driven by delicate protein networks whose functions are precisely
controlled by many parameters, such as number, distance, orientation, and position …

Live-cell super-resolved PAINT imaging of piconewton cellular traction forces

JM Brockman, H Su, AT Blanchard, Y Duan, T Meyer… - Nature …, 2020 - nature.com
Despite the vital role of mechanical forces in biology, it still remains a challenge to image
cellular force with sub-100-nm resolution. Here, we present tension points accumulation for …

Infrared nanosensors of piconewton to micronewton forces

N Fardian-Melamed, A Skripka, B Ursprung, C Lee… - Nature, 2025 - nature.com
Mechanical force is an essential feature for many physical and biological processes,,,,,–,
and remote measurement of mechanical signals with high sensitivity and spatial resolution …

Oriented triplex DNA as a synthetic receptor for transmembrane signal transduction

H Chen, S Zhou, K Ngocho, J Zheng, X He… - Nature …, 2024 - nature.com
Signal transduction across biological membranes enables cells to detect and respond to
diverse chemical or physical signals, and replicating these complex biological processes …

Hydrogel-based molecular tension fluorescence microscopy for investigating receptor-mediated rigidity sensing

W Wang, W Chen, C Wu, C Zhang, J Feng, P Liu… - Nature …, 2023 - nature.com
Extracellular matrix (ECM) rigidity serves as a crucial mechanical cue impacting diverse
biological processes. However, understanding the molecular mechanisms of rigidity sensing …

Periodically ordered, nuclease‐resistant DNA nanowires decorated with cell‐specific aptamers as selective theranostic agents

C Xue, S Zhang, X Yu, S Hu, Y Lu… - Angewandte Chemie, 2020 - Wiley Online Library
DNA nanostructures have shown potential in cancer therapy. However, their clinical
application is hampered by the difficulty to deliver them into cancer cells and susceptibility to …

A modular spring-loaded actuator for mechanical activation of membrane proteins

A Mills, N Aissaoui, D Maurel, J Elezgaray… - Nature …, 2022 - nature.com
How cells respond to mechanical forces by converting them into biological signals underlie
crucial cellular processes. Our understanding of mechanotransduction has been hindered …

Astigmatic traction force microscopy (aTFM)

D Li, H Colin-York, L Barbieri, Y Javanmardi… - Nature …, 2021 - nature.com
Quantifying small, rapidly progressing three-dimensional forces generated by cells remains
a major challenge towards a more complete understanding of mechanobiology. Traction …

Ultrafast DNA sensors with DNA framework-bridged hybridization reactions

F Li, X Mao, F Li, M Li, J Shen, Z Ge… - Journal of the …, 2020 - ACS Publications
Intracellular DNA-based hybridization reactions generally occur under tension rather than in
free states, which are spatiotemporally controlled in physiological conditions. However, how …