Directed evolution: methodologies and applications

Y Wang, P Xue, M Cao, T Yu, ST Lane… - Chemical reviews, 2021 - ACS Publications
Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

Biocatalysis: enzymatic synthesis for industrial applications

S Wu, R Snajdrova, JC Moore… - Angewandte Chemie …, 2021 - Wiley Online Library
Biocatalysis has found numerous applications in various fields as an alternative to chemical
catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for …

Stereodivergent atom-transfer radical cyclization by engineered cytochromes P450

Q Zhou, M Chin, Y Fu, P Liu, Y Yang - Science, 2021 - science.org
Naturally occurring enzymes can be a source of unnatural reactivity that can be molded by
directed evolution to generate efficient biocatalysts with valuable activities. Owing to the lack …

Machine learning in enzyme engineering

S Mazurenko, Z Prokop, J Damborsky - ACS Catalysis, 2019 - ACS Publications
Enzyme engineering plays a central role in develo** efficient biocatalysts for
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …

Biokatalyse: Enzymatische Synthese für industrielle Anwendungen

S Wu, R Snajdrova, JC Moore, K Baldenius… - Angewandte …, 2021 - Wiley Online Library
Die Biokatalyse hat in verschiedenen Einsatzgebieten Anwendung als Alternative zur
chemischen Katalyse gefunden, wobei die herausragendsten Beispiele die Herstellung …

The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis

RA Sheldon, D Brady, ML Bode - Chemical science, 2020 - pubs.rsc.org
Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …

Embracing nature's catalysts: a viewpoint on the future of biocatalysis

B Hauer - Acs Catalysis, 2020 - ACS Publications
Enzymes are nature's catalysts that are designed to accelerate specific reactions up to 106
times with high selectivity. 1 The enormous potential of enzymes as catalysts for organic …

The rise of continuous flow biocatalysis–fundamentals, very recent developments and future perspectives

P De Santis, LE Meyer, S Kara - Reaction Chemistry & Engineering, 2020 - pubs.rsc.org
Biocatalysis community has witnessed a drastic increase in the number of studies for the use
of enzymes in continuously operated flow reactors. This significant interest arose from the …

Immobilization of lipases on hydrophobic supports: immobilization mechanism, advantages, problems, and solutions

RC Rodrigues, JJ Virgen-Ortíz, JCS Dos Santos… - Biotechnology …, 2019 - Elsevier
Lipases are the most widely used enzymes in biocatalysis, and the most utilized method for
enzyme immobilization is using hydrophobic supports at low ionic strength. This method …

Large-scale production of enzymes for biotechnology uses

A Fasim, VS More, SS More - Current opinion in biotechnology, 2021 - Elsevier
Enzymes are biocatalysts that speed up the chemical reaction to obtain the final valuable
product/s. Biotechnology has revolutionized the use of traditional enzymes to be applicable …