Obtaining genetics insights from deep learning via explainable artificial intelligence
Artificial intelligence (AI) models based on deep learning now represent the state of the art
for making functional predictions in genomics research. However, the underlying basis on …
for making functional predictions in genomics research. However, the underlying basis on …
Deciphering the multi-scale, quantitative cis-regulatory code
S Kim, J Wysocka - Molecular cell, 2023 - cell.com
Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …
Legalbench: A collaboratively built benchmark for measuring legal reasoning in large language models
The advent of large language models (LLMs) and their adoption by the legal community has
given rise to the question: what types of legal reasoning can LLMs perform? To enable …
given rise to the question: what types of legal reasoning can LLMs perform? To enable …
A guide to machine learning for biologists
The expanding scale and inherent complexity of biological data have encouraged a growing
use of machine learning in biology to build informative and predictive models of the …
use of machine learning in biology to build informative and predictive models of the …
Multimodal deep learning for biomedical data fusion: a review
SR Stahlschmidt, B Ulfenborg… - Briefings in …, 2022 - academic.oup.com
Biomedical data are becoming increasingly multimodal and thereby capture the underlying
complex relationships among biological processes. Deep learning (DL)-based data fusion …
complex relationships among biological processes. Deep learning (DL)-based data fusion …
The evolution, evolvability and engineering of gene regulatory DNA
Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …
Time-series representation learning via temporal and contextual contrasting
Learning decent representations from unlabeled time-series data with temporal dynamics is
a very challenging task. In this paper, we propose an unsupervised Time-Series …
a very challenging task. In this paper, we propose an unsupervised Time-Series …
Navigating the pitfalls of applying machine learning in genomics
The scale of genetic, epigenomic, transcriptomic, cheminformatic and proteomic data
available today, coupled with easy-to-use machine learning (ML) toolkits, has propelled the …
available today, coupled with easy-to-use machine learning (ML) toolkits, has propelled the …
[HTML][HTML] High-throughput proteomics: a methodological mini-review
Proteomics plays a vital role in biomedical research in the post-genomic era. With the
technological revolution and emerging computational and statistic models, proteomic …
technological revolution and emerging computational and statistic models, proteomic …
[HTML][HTML] Approval of artificial intelligence and machine learning-based medical devices in the USA and Europe (2015–20): a comparative analysis
UJ Muehlematter, P Daniore… - The Lancet Digital Health, 2021 - thelancet.com
There has been a surge of interest in artificial intelligence and machine learning (AI/ML)-
based medical devices. However, it is poorly understood how and which AI/ML-based …
based medical devices. However, it is poorly understood how and which AI/ML-based …