Obtaining genetics insights from deep learning via explainable artificial intelligence

G Novakovsky, N Dexter, MW Libbrecht… - Nature Reviews …, 2023 - nature.com
Artificial intelligence (AI) models based on deep learning now represent the state of the art
for making functional predictions in genomics research. However, the underlying basis on …

Deciphering the multi-scale, quantitative cis-regulatory code

S Kim, J Wysocka - Molecular cell, 2023 - cell.com
Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Legalbench: A collaboratively built benchmark for measuring legal reasoning in large language models

N Guha, J Nyarko, D Ho, C Ré… - Advances in …, 2024 - proceedings.neurips.cc
The advent of large language models (LLMs) and their adoption by the legal community has
given rise to the question: what types of legal reasoning can LLMs perform? To enable …

A guide to machine learning for biologists

JG Greener, SM Kandathil, L Moffat… - Nature reviews Molecular …, 2022 - nature.com
The expanding scale and inherent complexity of biological data have encouraged a growing
use of machine learning in biology to build informative and predictive models of the …

Multimodal deep learning for biomedical data fusion: a review

SR Stahlschmidt, B Ulfenborg… - Briefings in …, 2022 - academic.oup.com
Biomedical data are becoming increasingly multimodal and thereby capture the underlying
complex relationships among biological processes. Deep learning (DL)-based data fusion …

The evolution, evolvability and engineering of gene regulatory DNA

ED Vaishnav, CG de Boer, J Molinet, M Yassour, L Fan… - Nature, 2022 - nature.com
Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …

Time-series representation learning via temporal and contextual contrasting

E Eldele, M Ragab, Z Chen, M Wu, CK Kwoh… - arxiv preprint arxiv …, 2021 - arxiv.org
Learning decent representations from unlabeled time-series data with temporal dynamics is
a very challenging task. In this paper, we propose an unsupervised Time-Series …

Navigating the pitfalls of applying machine learning in genomics

S Whalen, J Schreiber, WS Noble… - Nature Reviews Genetics, 2022 - nature.com
The scale of genetic, epigenomic, transcriptomic, cheminformatic and proteomic data
available today, coupled with easy-to-use machine learning (ML) toolkits, has propelled the …

[HTML][HTML] High-throughput proteomics: a methodological mini-review

M Cui, C Cheng, L Zhang - Laboratory investigation, 2022 - Elsevier
Proteomics plays a vital role in biomedical research in the post-genomic era. With the
technological revolution and emerging computational and statistic models, proteomic …

[HTML][HTML] Approval of artificial intelligence and machine learning-based medical devices in the USA and Europe (2015–20): a comparative analysis

UJ Muehlematter, P Daniore… - The Lancet Digital Health, 2021 - thelancet.com
There has been a surge of interest in artificial intelligence and machine learning (AI/ML)-
based medical devices. However, it is poorly understood how and which AI/ML-based …