Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …

It is well established that a wide variety of phenomena in cellular and molecular biology
involve anomalous transport eg the statistics for the motility of cells and molecules are …

INTRODUCTION DNA binding transcription factors (TFs) are quintessential regulators of
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding …

Folding of mammalian genomes into spatial domains is critical for gene regulation. The
insulator protein CTCF and cohesin control domain location by folding domains into loop …

Fixing cells with paraformaldehyde (PFA) is an essential step in numerous biological
techniques as it is thought to preserve a snapshot of biomolecular transactions in living cells …

RNA Polymerase II (Pol II) and transcription factors form concentrated hubs in cells via
multivalent protein-protein interactions, often mediated by proteins with intrinsically …

Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization
in such search is uncharted. Here we analyzed how multiple factors explore chromatin …

Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high
expression of oncogenes through gene amplification and altered gene regulation. Gene …

During mitosis, transcription is shut off, chromatin condenses, and most transcription factors
(TFs) are reported to be excluded from chromosomes. How do daughter cells re-establish …

Current models propose that boundaries of mammalian topologically associating domains
(TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by …